Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-551-4 | CAS number: 97-00-7
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No quantitative data, no strutural nformation regarding the measured metabolites
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity of and biological monitoring for 1,3-Diamino-2,4,6-trinitrobenzene and other nitro-amino derivatives of benzene and chlorobenzene
- Author:
- Watanabe, T.; Ishihara, N.; Ikeda, M.
- Year:
- 1 976
- Bibliographic source:
- Int. Arch. Occup. Environ. Hlth. 37,, 157-168 (1976)
Materials and methods
- Objective of study:
- other: development of a method for biomonitoring
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- A method for qualitative detection of test substance / metabolites was developed
- GLP compliance:
- no
- Remarks:
- predates GLP
Test material
- Reference substance name:
- 1-chloro-2,4-dinitrobenzene
- EC Number:
- 202-551-4
- EC Name:
- 1-chloro-2,4-dinitrobenzene
- Cas Number:
- 97-00-7
- Molecular formula:
- C6H3ClN2O4
- IUPAC Name:
- 1-chloro-2,4-dinitrobenzene
- Details on test material:
- no data, except the name
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- propylene glycol
- Duration and frequency of treatment / exposure:
- single injection
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100µMol/kg bw ( 20,256 mg/kg bw
- No. of animals per sex per dose / concentration:
- no data
- Control animals:
- not specified
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on excretion:
- DNCB and/ or metabolites are excreted via uriine in the rat.
Metabolite characterisation studies
- Metabolites identified:
- no
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): bioaccumulation potential cannot be judged based on study results
DNCB is excreted via urine in the rat.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
