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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 14 September 2015 - 13 February 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- An OECD 121 GLP study for a similar substance is available and is used within a read-across approach. The composition of source and target substance is described and discussed in detail in the attached supporting information as well as the read-across justification.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- other: mobile phase
- Specific details on test material used for the study:
- Target substance:
Amidoamine 2 (UVCB, low nitrogen):
Former chemical name: Amides, from diethylenetriamine and hydrogenated palm oil
CAS No.: 1618093-67-6
New chemical name: Glycerides, C16-18 (even numbered) and their amidation products with diethylenetriamine
Physical state: pale yellowish solid at 20 °C
Batch No.: PU50070067
Purity: 100 % (UVCB)
Storage condition of test material: Room temperature, protected from light
Stability: stable under test conditions - Radiolabelling:
- no
- Test temperature:
- 30 °C
- Details on study design: HPLC method:
- The sample, dead time and reference standard solutions were injected in duplicate using the
following HPLC parameters:
HPLC System: Agilent Technologies 1200 Series
Detector types: Ultraviolet (VWD)
Evaporative light scattering (ELSD)
Column: Waters XSelect Cyano, 5 µm (150 x 4.6 mm id)
Column temperature: 30 °C
Mobile phase A: Methanol: water adjusted to pH ~3 using trifluoroacetic acid
Mobile phase B: Methanol: THF
A calibration curve was constructed from the retention time data of the dead time and reference standard solutions. The capacity factors, k', for the reference standards were calculated. A correlation of log k' versus log Koc of the calibration standards was plotted using linear regression. - Analytical monitoring:
- yes
- Details on sampling:
- Test item was diluted to 100 mL with tetrahydrofuran (THF).
- Details on matrix:
- A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used.
- Key result
- Sample No.:
- #1
- Type:
- log Koc
- Value:
- > 5.63 dimensionless
- pH:
- 3
- Temp.:
- 30 °C
- Matrix:
- HPLC column containing lipophilic and polar moieties
- Key result
- Sample No.:
- #1
- Type:
- Koc
- Value:
- > 427 000 dimensionless
- pH:
- 3
- Temp.:
- 30 °C
- Matrix:
- HPLC column containing lipophilic and polar moieties
- Details on results (HPLC method):
- The test system utilized a high performance liquid chromatograph. A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used. The dead time was determined by measuring the retention time of formamide (purity: 99.94%, 0.612 g/L solution in mobile phase).
Solutions of reference standards, e.g. Acetanilide, Naphthalene and DDT were prepared in methanol. A calibration curve was constructed from the retention time data of the dead time and reference standard solutions. The mobility classification of the test item was obtained by comparing the calculated Koc
value to the mobility classes according to P.J. McCall, R.L. Swann, D.A. Laskowski, S.M. Unger, S.A. Vrona and H.J. Dishburger “Estimation of Chemical Mobility in Soil from Liquid Chromatography Retention Times”; Bull. Environm. Contam. Toxicol. 24, 190-195 (1980). - Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient (Koc) of the test item has been determined to be greater than 4.27 x 10^5, log10 Koc > 5.63. These values indicate that the test item will be essentially immobile in the environment.
It is considered likely, that the target substance Amidoamine 2 (UVCB, low nitrogen) will have a comparable adsorption coefficient (Koc > 5) as Amidoamine (UVCB) based on the similar chemical composition. - Executive summary:
The adsorption and desorption of amidoamine test item was determined in a Klimisch 1 GLP study according to EC C.19 and OECD 121. The adsorption coefficient (Koc) of the test item has been determined to be greater than 4.27 x 10^5, log10 Koc >5.63. These values indicate that the test item will be essentially immobile in the environment. This study is considered relevant for the risk assessment. It is considered likely, that the target substance Amidoamine 2 (UVCB, low nitrogen) will have a comparable adsorption coefficient (Koc > 5) as Amidoamine (UVCB) based on the similar chemical composition. It is expected that the higher concentration of saturated mono- and diglycerides and the presence of saturated triglycerides in Amidoamine 2 (UVCB, low nitrogen) will have no significant effect on the partition coefficient.
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14 September 2015 - 13 February 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- other: mobile phase
- Specific details on test material used for the study:
- Test item without emulsifier was investigated.
Source substance:
Amidoamine (UVCB)
Pulcra ID: DE07_2014_012_BEL66 (amidoamine without emulsifier)
Former chemical name: Amides, from diethylenetriamine and hydrogenated palm oil
Former CAS No.: 1618093-67-6
New chemical name: Triglycerides, C16-18 (even-numbered), reaction products with diethylenetriamine
Physical state: pale yellowish solid at 20 °C
Batch No.: K8 4309 L481
Expiry date of batch: 09 March 2018
Purity: 100 % (UVCB)
Stability: stable under test conditions
Storage condition of test material: Room temperature, protected from light
Target substance:
Amidoamine 2 (UVCB, low nitrogen):
Former chemical name: Amides, from diethylenetriamine and hydrogenated palm oil
CAS No.: 1618093-67-6
New chemical name: Glycerides, C16-18 (even numbered) and their amidation products with diethylenetriamine
Physical state: pale yellowish solid at 20 °C
Batch No.: PU50070067
Purity: 100 % (UVCB)
Storage condition of test material: Room temperature, protected from light
Stability: stable under test conditions - Radiolabelling:
- no
- Test temperature:
- 30 °C
- Details on study design: HPLC method:
- The sample, dead time and reference standard solutions were injected in duplicate using the
following HPLC parameters:
HPLC System: Agilent Technologies 1200 Series
Detector types: Ultraviolet (VWD)
Evaporative light scattering (ELSD)
Column: Waters XSelect Cyano, 5 µm (150 x 4.6 mm id)
Column temperature: 30 °C
Mobile phase A: Methanol: water adjusted to pH ~3 using trifluoroacetic acid
Mobile phase B: Methanol: THF
A calibration curve was constructed from the retention time data of the dead time and reference standard solutions. The capacity factors, k', for the reference standards were calculated. A correlation of log k' versus log Koc of the calibration standards was plotted using linear regression. - Analytical monitoring:
- yes
- Details on sampling:
- Test item was diluted to 100 mL with tetrahydrofuran (THF).
- Details on matrix:
- A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used.
- Key result
- Sample No.:
- #1
- Type:
- log Koc
- Value:
- > 5.63 dimensionless
- pH:
- 3
- Temp.:
- 30 °C
- Matrix:
- HPLC column containing lipophilic and polar moieties
- Key result
- Sample No.:
- #1
- Type:
- Koc
- Value:
- > 427 000 dimensionless
- pH:
- 3
- Temp.:
- 30 °C
- Matrix:
- HPLC column containing lipophilic and polar moieties
- Details on results (HPLC method):
- The test system utilized a high performance liquid chromatograph. A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used. The dead time was determined by measuring the retention time of formamide (purity: 99.94%, 0.612 g/L solution in mobile phase).
Solutions of reference standards, e.g. Acetanilide, Naphthalene and DDT were prepared in methanol. A calibration curve was constructed from the retention time data of the dead time and reference standard solutions. The mobility classification of the test item was obtained by comparing the calculated Koc
value to the mobility classes according to P.J. McCall, R.L. Swann, D.A. Laskowski, S.M. Unger, S.A. Vrona and H.J. Dishburger “Estimation of Chemical Mobility in Soil from Liquid Chromatography Retention Times”; Bull. Environm. Contam. Toxicol. 24, 190-195 (1980). - Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient (Koc) of the test item has been determined to be greater than 4.27 x 10^5, log10 Koc >5.63. These values indicate that the test item will be essentially immobile in the environment.
- Executive summary:
The adsorption and desorption of amidoamine test item was determined in a Klimisch 1 GLP study according to EC C.19 and OECD 121. The adsorption coefficient (Koc) of the test item has been determined to be greater than 4.27 x 10^5, log10 Koc >5.63. These values indicate that the test item will be essentially immobile in the environment. This study is considered relevant for the risk assessment.
Referenceopen allclose all
Description of key information
The adsorption coefficient (Koc) of the test item has been determined to be greater than 4.27 x 10^5, log10 Koc >5.63. These values indicate that the test item will be essentially immobile in the environment.
It is considered likely, that the target substance Amidoamine 2 (UVCB, low nitrogen) will have a comparable adsorption coefficient (Koc > 5) as Amidoamine (UVCB) based on the similar chemical composition. It is expected that the higher concentration of saturated mono- and diglycerides and the presence of saturated triglycerides in Amidoamine 2 (UVCB, low nitrogen) will have no significant effect on the partition coefficient.
Key value for chemical safety assessment
- Koc at 20 °C:
- 427 000
Additional information
Log Koc: > 5.63
Koc: > 427000
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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