Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 947-618-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Version / remarks:
- 2008
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Remarks:
- HPLC analysis and UV/VIS-detection
- Details on sampling:
- Chemical analysis
Storage: Routinely, the samples were analysed immediately. Only in exceptional cases, they were stored overnight deep frozen and protected from light. - Vehicle:
- no
- Details on test solutions:
- A stock solution was prepared to give the desired series of test concentrations. 1000.5 mg of the test item were added to 10 litres of dilution water, treated for 1 h in an ultrasonic bath and stirred for 24 h on a magnetic stirrer. The pH was measured to be 8.0. To produce the different test item concentrations appropriate amounts of the stock solution were diluted with dilution water to a volume of 5000 mL. Finally 7 fish were given to all test item concentrations and the control.
Auxiliaries used to prepare the test media were an ultrasonic bath and a magnetic stirrer.
Stability of test concentration/s during exposure : Examined by chemical analysis (HPLC) at 0, 24, 48, 72 and 96 hours. - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- Source : Interaquaristik.de Shop (Germany)
Date supplied : 2016-06-15
Acclimatisation : Stock held since 2016-06-15 and acclimatised to the test conditions since then.
Temperature : 20 - 24 °C
Dissolved oxygen : > 5 mg/L
Feeding : Commercial fish food, daily. Feeding discontinued 24 h prior to test start.
Mortalities during acclimatisation period : < 5 %
Medication : none
Mean standard length (n = 21) : 3.57 cm (S.D. = 0.14 cm) - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 13.3 °dH (= 237 mg/L CaCO3)
- Test temperature:
- 21.8 to 22.1 °C (with a maximum temperature fluctuation of +/- 0.7 °C in the test)
- pH:
- 7.6 - 8.0
- Dissolved oxygen:
- 7.8 - 8.9 mg/L (Oxygen saturation 91 - 100 %)
- Nominal and measured concentrations:
- Test item concentration/s : 50 and 100 mg/L
- Details on test conditions:
- Exposure conditions
Test vessels : glass aquaria holding 5 L of test media covered by glass plates
Experimental design : 2 test concentrations plus 1 control, 7 fish per test concentration, no feeding during the exposure period, static system
Method of initiation : fish were placed in prepared media
Loading : 0.81 g body weight (wet weight) per litre
Photoperiod : 16 h light: 8 h dark
Temperature : 21.4 to 22.1 °C
Aeration : gentle aeration via narrow glass tubes
Method of administration : stock solution
Medium renewal : none - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- The criterion of death used in this study was the absence of response to physical stimulation. In addition to observations on mortality at 2, 24, 48, 72 and 96 hours, type and incidence of sub-lethal effects compared with control fish were observed.
Effective concentrations ranged from 100.1 % to 100.5 % of nominal values at 96 hours. - Reported statistics and error estimates:
- As no toxic effects against fish were observed, no statistical analysis was required to determine the LC 50.
- Sublethal observations / clinical signs:
Some test fish had a somewhat larger size than the one recommended in the test guideline for the zebra fish. This deviation is not regarded to be relevant to the results.
- Validity criteria fulfilled:
- yes
- Remarks:
- The mortality in the controls did not exceed 10 % by the end of the test. The dissolved oxygen concentration remained above 60 % of the air-saturation value throughout the exposure period. The pH did not vary by more than 1 unit.
- Conclusions:
- No toxic effects against fish were observed up to a test item, EGGE 2806-1, concentration of 100 mg/L.
- Executive summary:
A study was performed to assess the acute toxicity of EGGE 2806-1 to Danio rerio under static conditions. The study was conducted in accordance with GLP and OECD Guideline for Testing of Chemicals No. 203 'Fish, Acute Toxicity Test' (1992). Groups of seven fish of the recommended size were exposed to a range of concentrations, nominally 50 and 100 mg/L of EGGE 2806-1 dissolved in dilution water. Observations were made on the numbers of dead fish and the incidence of sub-lethal effects after 2, 24, 48, 72 and 96 hours of exposure. No toxic effects against fish were observed up to a test item concentration of 100 mg/L (LC50 > 100 mg/L after 96 h). All results are expressed in terms of nominal concentrations.
Reference
Description of key information
A study was performed to assess the acute toxicity of EGGE 2806-1 to Danio rerio under static conditions. The study was conducted in accordance with GLP and OECD Guideline for Testing of Chemicals No. 203 'Fish, Acute Toxicity Test' (1992). Groups of seven fish of the recommended size were exposed to a range of concentrations, nominally 50 and 100 mg/L of EGGE 2806-1 dissolved in dilution water. Observations were made on the numbers of dead fish and the incidence of sub-lethal effects after 2, 24, 48, 72 and 96 hours of exposure. No toxic effects against fish were observed up to a test item concentration of 100 mg/L (LC50 > 100 mg/L after 96 h). All results are expressed in terms of nominal concentrations.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 100 mg/L
Additional information
Should read >100 mg/L
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.