oligomeric reaction product of 2-hydroxybenzaldehyde with 1-chloro-2,3-epoxypropane and phenol

Adsorption / desorption

Link to relevant study record(s)

Reference

Endpoint:

adsorption / desorption: screening

Type of information:

experimental study

Adequacy of study:

key study

Study period:

26 October 2015- 26 November 2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

HPLC estimation method

Media:

soil/sewage sludge

Test temperature:

20 °C

Details on study design: HPLC method:

Preparation of the Test Solutions:
Reference substances and Test Item were dissolved in acetonitrile. Concentration of these stock solutions was about 1 mg/ml. These stock solutions were diluted with eluent resulting about 10 µg/ml (Test Item and reference substances).

Determination of the retention times:
Three series of the above reference solutions and the Test Item solution were measured alternately, with two replicate injections. For the determination of t0 (t0 = retention time of the unretarded component) sodium nitrate solution was injected. The retention times were determined.

Column: LiChrospher 100CN 250×4.6 mm, 5µm
Mobil Phase: Acetonitrile:water = 1:1
Flow: 1.0 ml/min.
Injection volume: 10 µl
Temperature: 25 °C
Detector: 230 nm

Key result

Sample No.:

#1

Type:

log Koc

Value:

> 3.55 - < 4.72 dimensionless

Temp.:

25 °C

Details on results (HPLC method):

The three calibration series and three Test Item series were measured alternately. The adsorption coefficient Koc was determined based on a calibration curve using 6 reference items. The capacity factors were calculated from the dead time and retention times of the reference substances. The log k data of the reference substances were plotted against their log Koc values. The equation of the curve fitted to the calibration points is as follows:
log k = 0.146 × log Koc + 0.101 (Rsq = 0.978)

Validity criteria fulfilled:

yes

Conclusions:

The capacity factors logk and logKoc for Test Item were calculated based on the calibration data obtained with the reference substances.
The estimated logKoc is in the range of 3.55- 4.72.

Executive summary:

The capacity factors logk and logKoc for Test Item were calculated based on the calibration data obtained with the reference substances.  

The estimated logKoc is in the range of 3.55- 4.72.  

Description of key information

The capacity factors logk and logKoc for Test Item were calculated based on the calibration data obtained with the reference substances.  

The estimated logKoc is in the range of 3.55- 4.72.  

Key value for chemical safety assessment

Koc at 20 °C:

52 481

Additional information

[LogKoc: 4.72]