Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 690-796-1 | CAS number: 420-16-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In the key study (BASF, 2012) of skin corrosion, the test substance shows a corrosive potential in the Corrositex® test. No test was performed on eye irritation, as the complex is composed of boron trifluoride and acetonitrile and both substances are considered as corrosive to eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
- GLP compliance:
- yes (incl. QA statement)
- Species:
- other: reconstituted collagen matrix
- Strain:
- other: not applicable
- Type of coverage:
- other: not applicable
- Preparation of test site:
- other: not applicable
- Controls:
- other: not applicable
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 500 µL
- Concentration (if solution): undiluted - Duration of treatment / exposure:
- up to 4 hours or until break through
- Observation period:
- Test substance: 3 min to 4 hours or until break through
Negative control: 60 min
Positive control: continuously until break through - Number of animals:
- 4 tests were performed for the test item, one test for the positive, negative and the blank control, respectively.
- Details on study design:
- The Corrositex® Biobarrier Membrane is a test system consisting of a reconstituted collagen matrix. The assay is based on the time that is required for the test substance to penetrate through the Corrositex® Biobarrier Membrane and produce a change in the Chemical Detection System (CDS). The Corrositex® assay is used to determine the corrosive potential of test substances. But the assay is limited to testing those materials which cause detectable pH changes in the CDS.
First, 150 μL of the test substance was added to the CDS screening tube. If the test substance failed to produce a color change in the CDS within one minute, the test substance could not be analyzed in this system, and no further testing was required. In the main test, one vial was used for the PC, NC and for the color (blank) control, each. A membrane disc coated with the biobarrier matrix was placed into one vial containing the CDS and approximately 500 μL of the test substance was added onto the membrane disc. An electronic time clock was started with the application. The vial was observed for three minutes for any change in the CDS. If no color change was observed within three minutes, the remaining membranes were treated with the test substance. An electronic time clock was started with each application. The vials were observed continuously for the first ten minutes. Thereafter the vials were observed for approximately ten minutes around the time points relevant for evaluation or until break through of the test substance occurred. The elapsed time between test-substance application and the first change in the indicator solution (i.e. barrier penetration) was recorded.
Reference
Break through time:
Substance | Break through time [min:s] | Mean [test item] break though time [min:s] | |||
Test item | 8:07 | 8:20 | 9:28 | 8:48 | 8:41 |
positive control | 10:21 | ||||
negative control | no break through |
positive control: Sodium hydroxide, solid
negative control: 10% citric acid
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation/Corrosion
In the key study (BASF, 2012) for skin corrosion, the test item was tested according to OECD no.435. The test item shows a corrosive potential in the Corrositex® test. In another study (Hilaski, R.J., 1997), the read across substance acetonitrile (CAS no. 75 -5 -8) was found to be non-irritating to the skin of rabbits (4 -hour exposure). All scores at each observation interval were 0.0 for each animal. No other signs of ill health or test article-related effects were observed during the study.
Eye irritation
No test with the complex was performed on eye irritation since boron trifluoride is classified as skin and eye corrosive. Clinical signs of respiratory distress were observed during short term and long term inhalation toxicity studies with the read across substances BF3 or BF3 dihydrate, even at low concentrations.
In the key study (OECD 405 equivalent, GLP, Hilaski, R.J., 1997), the read across substance acetronitrile (CAS no. 75-05 -8) was found to be severely irritating to the eyes of rabbits, with a maximum group average ocular Draize irritation score of 46.0 occurring at 24 hours postdose. Considerable ocular irritation was observed in all animals, including easily discernible corneal opacity, slight iris injection, diffuse beefy red conjunctivae, obvious swelling, partial lid eversion, and considerable discharge. Some ocular irritation was present in 4 of 6 animals at study termination 21 days after dosing. No other signs of ill health or toxicity were observed during the study.
Respiratory irritation
Taking
the acute inhalation results of the read across substances (see IUCLID
chapter 7.2.2) into account, it can be assumed that the test substance
will lead to respiratory irritation when inhaled.
Justification for selection of eye irritation endpoint:
Waiver addresses corrosiveness to eyes of the substance.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
- boron trifluoride: C (R35: Causes severe burns)
- acetonitrile: Xi (R36: Irritating to eyes)
Classification, Labelling, and Packing Regulation (EC) No. 1272/2008, Table 3.1 List of harmonised classification and labelling of hazardous substances:
- boron trifluoride: Skin Corr. 1A (H314: Causes severe skin burns and eye damage.)
- acetonitrile: Eye Irrit. 2 (H319: Causes serious eye irritation.) [Separate legal classification of boron trifluoride dihydrate (CAS 13319-75-0) is not available.]
Considering legal classification and study results, the complex of boron trifluoride with acetonitrile should be classified with respect to acute toxicity as follows:
Dangerous Substance Directive (67/548/EEC)
Based on the available data it the test item is considered to be classified as corrosive to eye and skin (C, R35 Causes severe burns) and irritant to the respiratory tract (R37 irritating to respiratory system) under Directive 67/548/EEC, as amended for the 31st time in Directive 2009/2/EC.
Classification, Labeling, and Packaging Regulation (EC) No 1272/2008
Based on the available data the test substance is considered to be classified for as corrosive to eye and skin (Skin Corr. 1A, H314 Causes severe skin burns and eye damage) and as irritant to the respiratory tract (H335 May cause respiratory irritation) under Regulation (EC) No. 1272/2008, as amended for the sixth time in Regulation (EC) No 605/2014.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.