Registration Dossier
Registration Dossier
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EC number: 700-591-1 | CAS number: 82203-23-4
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: non-GLP guideline study, but test procedure well documented
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- see 'Principles of method if other than guideline'
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- yes
- Remarks:
- see 'Principles of method if other than guideline'
- Principles of method if other than guideline:
- In an agitated and filtrated mixture of the test item, a concentration below 10 mg/L was measured during validation. Therefore, the preliminary study was not performed. Solubility could be limited as lying below 10 mg/L and the main study was conducted using the column elution method.
- GLP compliance:
- no
- Type of method:
- column elution method
Test material
- Reference substance name:
- (1R)-1-[(4R,4aR,8aS)-2,6-bis(4-chlorophenyl)-hexahydro-[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol
- EC Number:
- 700-591-1
- Cas Number:
- 82203-23-4
- Molecular formula:
- C20H20Cl2O6
- IUPAC Name:
- (1R)-1-[(4R,4aR,8aS)-2,6-bis(4-chlorophenyl)-hexahydro-[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol
- Details on test material:
- - Name of test material (as cited in study report): (1R)-1-[(4R,4aR,8aS)-2,6-bis(4-chlorophenyl)tetrahydro[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol
- Expiration date of the lot/batch: December 2012
- Storage condition of test material: Room Temperature: (20 ± 5°C); Keep away from humidity
Constituent 1
Results and discussion
Water solubilityopen allclose all
- Water solubility:
- 0.33 mg/L
- Temp.:
- 22.5 °C
- pH:
- 6
- Remarks on result:
- other: Flow rate of 24.4 mL/hour, standard deviation is 0.013 mg/L
- Water solubility:
- 0.336 mg/L
- Temp.:
- 23.2 °C
- pH:
- 6
- Remarks on result:
- other: Flow rate of 12.3 mL/hour, standard deviation is 0.011 mg/L
- Water solubility:
- 0.333 mg/L
- Temp.:
- 22.85
- pH:
- 6
- Remarks on result:
- other: Total mean value, standard deviation is 0.012 mg/L
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results: slightly soluble (0.1-100 mg/L)
The water solubility of the test substance has been determined to be 0.333 mg/L (pH = 6; temperature ~ 23 °C) and therefore the substance is considered to be slightly soluble in water.
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