Alcohols, C10-16, ethoxylated, sulfates, mono(hydroxyethyl)ammonium salts

Solubility in organic solvents / fat solubility

Link to relevant study record(s)

Reference

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

16 Jun - 1 Jul 2016

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Qualifier:

according to guideline

Guideline:

other: OECD 105

Deviations:

yes

Remarks:

preliminary test only, due to gel formation

Principles of method if other than guideline:

Although the guideline OECD 105 refers to solubility in water, the protocol can be applied also for other type solvents, including organic ones, and in particular n-octanol.

GLP compliance:

no

Medium:

n-octanol

Solubility:

> 2 100 g/L

Temp.:

20 °C

Test substance stable:

yes

Preliminary test:

To 1.64 g of n-octanol, the following aliquots of test item were added:

Experiment	Weighed sample [g]	Result
A	0.0194	clear liquid
B	0.1192	clear liquid, yellowish
C	0.2685	clear liquid, yellowish
D	0.0073	clear liquid
E	0.0659	clear liquid
F	0.0950	clear liquid, yellowish
G	3.0880	clear liquid, yellowish
H	4.2193	clear liquid, yellowish

With 4.2193 g of test item being mixed into 1.64 g of n-octanol, a clear yellowish liquid with a total weight of 5.8593 g has been formed. This is equivalent to 72.0% (w/w) of test item in solution or a concentration of 2.11 kg/L.

The n-octanol solubility can be approximated to > 2100 g/L, or rather unlimited.

Description of key information

Solubility in n-octanol: > 2100 g/L, or rather unlimited, at 20 °C

Additional information

Because of the lack of a proper guideline for solubility in organic solvents, the solubility of the substance in n-octanol was determined in accordance with OECD 105, i.e the guideline for water solubility.