Registration Dossier
Registration Dossier
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EC number: 470-080-3 | CAS number: -
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Waiver:
The determination of the hydrolysis as a function of pH of 1-((2-Butyloctyloxymethyl)-2-(3,4-dihydro-isoquinolinium-2-yl)ethyl)sulfate is scientifically unjustified.
REACh-Regulation No. 1907/2006, Annex VIII, Sect. 9.2.2.1, Col. 2, states as follows:
“9.2.2.1. Hydrolysis as a function of pH:
The study does not need to be conducted if:
- the substance is readily biodegradable, or
- the substance is highly insoluble in water.”
The water solubility determination was performed according to column eluation method (OECD guideline 105). The water solubility of the 1-((2-Butyloctyloxymethyl)-2-(3,4-dihydro-isoquinolinium-2-yl)ethyl)sulfate amounts to 2.5 mg/L +/- 0.08 mg/L at T = 20.0°C +/- 0.1°C.
Thus, determination of the hydrolysis as a function of pH of 1-((2-Butyloctyloxymethyl)-2-(3,4-dihydro-isoquinolinium-2-yl)ethyl)sulfate is scientifically unjustified and not required under REACH.
Furthermore, EPIWIN (v. 4.00) software predicted no hydrolysis for the structure of 1-((2-Butyloctyloxymethyl)-2-(3,4-dihydro-isoquinolinium-2-yl)ethyl)sulfate.
Key value for chemical safety assessment
Additional information
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
