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Diss Factsheets
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EC number: 406-810-4 | CAS number: 40649-36-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- no
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- - Source of activated sludge: 1 L from the total effluent of a sludge plant and 1 L reflux from an activated sludge plant (ex Klärwerk Neuenfelde, Hamburg)
- Pretreatment: Tha activated sludge was filtered, discarding the first 200 mL. Further, 100 g of a standard soil (a mixture of humus and loamy soil from the region of Speyer) were dispersed in 1000 mL of demineralized water and then filtered, again discarding the first 200 mL of the filtrate. 100 mL of each filtrate were mixed for the composite inoculum. - Duration of test (contact time):
- 28 d
- Initial conc.:
- 1.007 g/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: Mineral nutrient solution according to OECD 301D
- Additional substrate: no
- Test temperature: 20 °C
- CEC (meq/100 g): not available
- Aeration of dilution water: yes
- Suspended solids concentration: not available
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: BOD-bottles
- Number of culture flasks/concentration: 3
- Measuring equipment: 0X1 530 with a TriOX E0 200-electrode (ex Wissenschaftlich-Technische Werkstätten GmbH, 8120 Weilheim i. OB)
- Test performed in open system: no
CONTROL AND BLANK SYSTEM
- Control series: distilled water with nutrient solutions without inoculum
- Blind series: distilled water with nutrient solutions with inoculum
- Reference series: a solution of sodium-n-dodecylsulfate (SDS) with nutrient solutions and inoculum
- Inhibition series: a solution of the test substance and SDS with nutrient solutions and inoculum - Reference substance:
- other: sodium-n-dodecylsulfate
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 1.2
- Sampling time:
- 28 d
- Details on results:
- For the test substance the following results were obtained: 0.0 % after 5 days, 0.0 % after 15 days, 1.2% after 28 days. Therefore, the test substance cannot be described as ready biodegradable under the test conditions.
For the test substance the following BOD-values can be given:
BOD (5 days) = 0.00 g O2/g test item
BOD (15 days) = 0.00 g O2/g test item
BOD (28 days) = 0.03 g O2/g test item - Parameter:
- BOD5
- Value:
- 0 g O2/g test mat.
- Results with reference substance:
- For the reference substance (as active substance (AS)) the following figures were obtained: 43.7 % after 5 days, 61.2 % after 15 days, 72.8 % after 28 days.
Inhibition test:
The difference A has negative value at the end of the test
A = 02-consumption (test substance + reference substance) -[02-consumption (test substance) + 02-consumption (reference substance)]
However, a significant inhibitory effect on the biodegradation of the reference substance can not be assumed. - Validity criteria fulfilled:
- yes
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The degradation rate of the test material was 1.2% after 28 days and did not reach 60 % within the 10-day window and after 28 days of incubation.Therefore the test substance cannot be described as ready biodegradable under the test conditions.
- Executive summary:
The test item was investigated for its ready biodegradability in a Closed Bottle Test over a period of 28 days according to OECD TG 301D. The biodegradation was followed by the oxygen depletion of the microorganisms during exposure. As a reference substance sodium-n-dodecylsulfate was tested simultaneously under the same conditions as the test item, and functioned as a procedure control. The oxygen depletion was measured after 5, 15, and 28 days by means of an oxygen electrode. Control- and blank-series without the test substance were run simultaneously and the effectiveness of the inoculum was confirmed (in a third series with sodium-n-dodecylsulfate as reference substance) and found to be 72.8 % after 28 days under the conditions of the test. The value of chemical oxygen demand (TOD) of the test substance was calculated to be 2.86 mg 02/mg active substance. For the test substance, a biodegradability of about 1.2 % (after 28 days) was found. Therefore the test substance cannot be described as ready biodegradable under the test conditions. Moreover it should be tested, whether the test substance exerts an inhibiting effect on biological degradation processes. As a result it was established that the test substance has no inhibiting effect on the biological degradation of the reference substance.
Reference
Description of key information
The degradation rate of the test material was 1.2% after 28 days and did not reach 60 % within the 10-day window and after 28 days of incubation. Therefore the test substance cannot be described as ready biodegradable under the test conditions (reference 5.2.1-1).
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
The test item was investigated for its ready
biodegradability in a Closed Bottle Test over a period of 28 days
according to OECD TG 301D. The biodegradation was followed by the oxygen
depletion of the microorganisms during exposure. As a reference
substance sodium-n-dodecylsulfate was tested simultaneously under the
same conditions as the test item, and functioned as a procedure control.
The oxygen depletion was measured after 5, 15, and 28 days by means of
an oxygen electrode. Control- and blank-series without the test
substance were run simultaneously and the effectiveness of the inoculum
was confirmed (in a third series with sodium-n-dodecylsulfate as
reference substance) and found to be 72.8 % after 28 days under the
conditions of the test. The value of chemical oxygen demand (TOD) of the
test substance was calculated to be 2.86 mg 02/mg active substance. For
the test substance, a biodegradability of about 1.2 % (after 28 days)
was found. Therefore the test substance cannot be described as ready
biodegradable under the test conditions. Moreover it should be tested,
whether the test substance exerts an inhibiting effect on biological
degradation processes. As a result it was established that the test
substance has no inhibiting effect on the biological degradation of the
reference substance (reference 5 .2.1-1).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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