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Diss Factsheets
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EC number: 301-037-8 | CAS number: 93980-59-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: Activated sludge obtained from site Kurume central sewage treatment center (Kurume-shi, Fukuoka, Japan), receiving predominantly domestic sewage
- Concentration of sludge: 30 mg/L (suspended solids) - Duration of test (contact time):
- 28 d
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: mineral medium according to guidelne
- Test temperature: 22±1 °C
- Continuous darkness: yes
- pH: 7.3 - 7.8 (at the end of exposure)
- Other: Test solutions were stirred continuously.
TEST SYSTEM
- Culturing apparatus: Closed system oxygen consumption measuring apparatus (No. CM-067)
- Number of culture flasks/concentration: 2
- Details of trap for CO2 and volatile organics if used: Soda lime No.1 (for absorption of carbon dioxide, Wako Pure Chemical Industries)
SAMPLING
- Sampling frequency: O2 consumption was measured continuously.
- Sampling method: automatic measurement without specific sampling
CONTROL AND BLANK SYSTEM
- Inoculum blank: 1
- Toxicity control: 1
- Reference substance: yes, 2 bottles - Reference substance:
- benzoic acid, sodium salt
- Parameter:
- % degradation (O2 consumption)
- Value:
- 13
- Sampling time:
- 28 d
- Remarks on result:
- other: mean of two replicates
- Details on results:
- The test item was not dissolved, the test solution was colorless.
In the test solution (sludge+ test item+ sodium benzoate) for checking the toxicity of the test item, the percentage biodegradation by BOD was 34% after 14 days. According to the test guideline, the test item can be assumed to be not inhibitory on the activated sludge microorganisms at the applied concentration level of 100 mg/L because the percentage biodegradation was > 25% within 14 days. - Results with reference substance:
- 99% after 14 days
- Validity criteria fulfilled:
- yes
- Remarks:
- For further details please refer to “Any other information on results incl. tables”.
- Interpretation of results:
- under test conditions no biodegradation observed
Reference
Table 1: Biodgradation rates
Sludge + test item | |||
Vessel No. 1 | Vessel No. 2 | Average | |
Percentage biodegradation by BOD after 28 days | 22 | 3 | 13 |
Percentage biodegradation by BOD at the end of the 10-day window |
22 | - | - |
Table 2: Validity criteria for OECD 301.
Criterion from the guideline |
Outcome |
Validity criterion fulfilled |
Difference of extremes of replicate values of the removal of the test chemical at the plateau, at the end of the test or at the end of the 10-d window, as appropriate, is less than 20%. |
19% |
yes |
Percentage degradation of the reference compound has reached the pass levels by day 14. |
99% at day 14 |
yes |
The toxicity control should degrade to at least 25% (based on ThOD or ThCO2) within 14 d. |
34% |
yes |
Description of key information
Not readily biodegradable according to OECD criteria (13% after 28 d, OECD 301F).
Key value for chemical safety assessment
Additional information
The available test on the ready biodegradability of the test substance was performed according to OECD Guideline 301 F. The biodegradability of the substance was assessed by following the O2 consumption of non-adapted activated sludge over 28 days. At test termination after 28 days a degradation rate of 13% based on O2 consumption was determined. The toxicity control (test substance + reference substance) achieved 34 % degradation after 14 days. Thus, inhibitory effects of the test substance on activated sludge microorganisms can be excluded. Based on the result the substance is considered not readily biodegradable according to OECD criteria.
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