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EC number: 297-083-0 | CAS number: 93334-10-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (3 h) of ≥ 100 mg/L for activated sludge microorganisms (OECD 209)
Key value for chemical safety assessment
Additional information
Since no studies investigating the toxicity of Fatty acids,
rape-oil, mixed esters with 1,4:3,6-dianhydro-d-glucitol, sorbitan and
sorbitol (CAS 93334-10-2) to microorganisms are available, in accordance
to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across was
conducted to the structurally related analogue substances sorbitane
isooctadecanoate (CAS 71902-01-7) and sorbitan monolaurate (CAS
1338-39-2).
This read-across is justified as all substances share a comparable
structure. Based on the specification the target substance Fatty acids,
rape-oil, mixed esters with 1,4:3,6-dianhydro-d-glucitol, sorbitan and
sorbitol is characterized by the alcohol components sorbitol, sorbitan
and 1,4:3,6-dianhydro-d-glucitol esterified as mono (mainly), -di- or
tri-ester with mainly fatty acids of C18 and C18 unsaturated. The source
substance sorbitan laurate (CAS 1338-39-2) is characterized as a mono-,
di- and tri-ester of sorbitol with mainly C12 fatty acids. Sorbitane
isooctadecanoate (CAS 71902-01-7) is an ester (mono, di and tri) of
sorbitan and 1,4:3,6-dianhydro-d-glucitol with C18 branched fatty acid.
Further justification is given within the endpoint summary 6.1 and
within the analogue justification in section 13.
The toxicity of the source substance sorbitan isooctadecanoate (CAS 71902-01-7) to microorganisms was tested in a toxicity control during a ready biodegradation study (OECD 301B). If a compound degrades well in a ready biodegradability test, or does not inhibit the degradation of a positive control at a certain concentration, this concentration can be used as a NOEC value. This approach is in accordance with the Guidance on information requirements and chemical safety assessment (Chapter R.7b: Endpoint specific guidance, ECHA 2012b). A substance can be assumed to be not inhibitory to aquatic microorganisms, if in the toxicity control of a ready biodegradation test, more than 25% degradation based on CO2 evolution (CO2/ThCO2) occurred within 14 days (OECD guideline 301). For sorbitan isooctadecanoate a biodegradation test according to OECD guideline 301 B is available (Clarke, 2012). The test includes a toxicity control, which contains 14.4 mg/L of sorbitan isooctadecanoate and 17.1 mg/L of the reference material sodium benzoate. The toxicity control attained 82% degradation after 14 days of incubation. Hence, the substance is not toxic to aquatic microorganisms in the toxicity control and the test item concentration of 14.4 mg/L can be used as a NOEC.
The toxicity of the second source substance sorbitan laurate (CAS 1338-39-2) to microorganisms was investigated as a limit test according to the OECD Guideline 209 and GLP (Desmares-Koopmans, 2010). Activated sludge of a predominantly domestic sewage was exposed to the test concentration of 100 mg/L during 3 hours. No effect on the respiration rate of the activated sludge was observed resulting in a NOEC (3 h) ≥ 100 mg/L.
Based on the result from two structurally related read across substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) it can be concluded that Fatty acids, rape-oil, mixed esters with 1,4:3,6-dianhydro-d-glucitol, sorbitan and sorbitol will not exhibit effects to microorganisms and will not inhibit the degradation process in sewage treatment plants.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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