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EC number: 294-436-0 | CAS number: 91722-33-7 A complex combination of organic compounds separated after condensation of the vapors from the destructive distillation of wood.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
As peaks 1, 2, 3, 8, 10, 11, 12, 13, 14 and 15 showed relative areas < 5 % (see table 9.2–
b in the study report), they were considered as minor peaks.
Although area is not necessarily correlated to absolute concentration if a UV detector is
used, it is assumed that the test item consists mainly of the peaks 4, 5, 6, 7 and 9. Using
the correlation log K / log POW, the log POW of the major components of test item Tar wood
was calculated as 0.239 ± 0.000 – 2.022 ± 0.000 (mean ± standard deviation). Due to the
fact that the calculated log POW of peak 4 lay outside the calibrated range, the log POW of
Tar wood should be stated as < 0.3 – 2.022 ± 0.000 (mean ± standard deviation).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.022
- at the temperature of:
- 25 °C
Additional information
This study was performed in order to estimate the distribution coefficient log POW of Tar
wood using HPLC.
The partition coefficient (POW) is defined as the ratio of the equilibrium concentrations of a
dissolved substance in a two-phase system consisting of two largely immiscible solvents
(n-octanol and water). The log POW is a key parameter in studies of the environmental fate
of chemical substances. A highly significant relationship between the POW of non-ionised
form of substances and their bioaccumulation in fish has been shown. It has also been
shown that POW is a useful parameter in the prediction of adsorption on soil and sediments
and for establishing quantitative structure-activity relationships for a wide range of biological
effects.
The HPLC method covers log POW in the range of 0 to 6. Reverse phase HPLC is performed
on analytical columns packed with a commercially available solid phase containing
long hydrocarbon chains (e.g. C8, C18) chemically bound onto silica.
A test item injected on such a column partitions between the mobile solvent phase and the
hydrocarbon stationary phase as it is transported along the column by the mobile phase.
The test items are retained in proportion to their hydrocarbon-water partition coefficient,
with hydrophilic chemicals eluted first and lipophilic chemicals last. The retention times of
the peaks of the test item are compared with retention times of reference substances with
known hydrocarbon-water partition coefficients.
Experimental data (retention times of peaks of the test item and of the reference items) are
used together with literature values for the log POW of the reference items to calculate the
log POW for the test item.
Variations in the retention times of reference items and test item are very small. Therefore
a stable configuration of the HPLC-column can be assumed.
The correlation log K/Log POW is good: the coefficient of determination r2 was calculated
with 0.9721. This value was considered as sufficiently high to use the calibration function
for the determination of the log POW of the test item Tar wood.
As peaks 1, 2, 3, 8, 10, 11, 12, 13, 14 and 15 showed relative areas < 5 %, they were considered
as minor peaks. Although area is not necessarily correlated to absolute concentration
if UV detection is used, it is assumed that the test item Tar wood consists mainly of
the peaks 4, 5, 6, 7 and 9.
Due to the fact that the calculated log POW of peak 4 lay outside the calibrated range, the
log POW of Tar wood should be stated as < 0.3 – 2.022 ± 0.004 (mean ± standard deviation).
No observations were made which might cause doubts concerning the validity of the study
outcome.
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