Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 281-161-6 | CAS number: 83877-91-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Hydrolytically unstable with the half-life time of < 10 minutes at 25 deg. C at pH 4, 7 and 9.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 10 min
- at the temperature of:
- 25 °C
Additional information
Study performed in accordance with GLP. However, as the substance is highly hydrolytically unstable it was not possible to perform the test as outlined in the guidelines. In order to obtain as much information on hydrolysis as possible, an alternative test was designed. The hydrolytic stability was tested in buffered aqueous solutions at pH 4.0, 7.0 and 9.0 at 25 0C for 40 minutes. The progress of hydrolysis was followed by monitoring ethyl acetoacetate and 2 -methylpropanol, the hydrolysis products of the substance. Based on the results, it was concluded that the hydrolysis half -life time for the substance was <10 minutes. Additionally, the formation of a white precipitation was observed during the hydrolysis study. This is most likely due to the formation of the insoluble titanium oxides.
Based on the Tier 3 approach, no other degradation products were identified at quantitative level. The response of the hydrolysis products ethyl acetoacetate and 2-methylpropanol was > 69% (area). In the chromatograms, small additional peaks with an area In the chromatograms, small additional peaks with an area < 1% were observed at 4.69 minutes, 5.31 minutes (at pH 7 and pH 9), 6.02 minutes and 6.97 minutes (at pH 4). Two additional peaks with an area > 1% were observed at the retention time of 2.92 and 3.26 minutes.
To achieve sufficient sensitivity for the analysis of the identified hydrolysis product, selected ion monitoring was used as detection method. Therefore it was not possible to obtain accurate information on the mass fraction of the unknown peaks nor to record their entire mass spectrum, and hence it was not possible to identify these additional peaks. However, the patterns of the three m/z values showing response for the peaks at 2.92 and 3.26 minutes, i.e. m/z 31, 43 and 45, show similarity with the responses found for ethanol and isopropyl alcohol, respectively. All additional peaks might derive from impurities in the test substance and/or hydrolysis products.
The results of this study are considered reliable to be used for C&L purposes to conclude this substance to be hydrolytically unstable releasing only 2 -methylpropanol and ethyl acetoacetate and hydrated titanium dioxide when in contact with water. Based on the results this substance can be considered as rapidly degradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.