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EC number: 271-517-9 | CAS number: 68583-52-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
There is no genetic toxicity information available for the test substance. An Ames mutagenicity study with the structurally similar ethane-1,2-diylbis(oxyethane-2,1-diyl) bisheptanoate (CAS 7434 -40 -4) was negative when tested in Salmonella strains TA98, TA100, TA1535, TA1537 and TA1538 up to a maximum plate incorporation level of 5000 uL/plate, either with or without metabolic activation.
The structurally similar material, heptanoic acid, oxybis(2,1-ethanediyloxy-2,1-ethanediyl) ester (CAS 70729 -40 -9), was negative in a CHO HGPRT mammalian cell mutagenicity study either with or without metabolic activation.
The structurally similar material, heptanoic acid, ester with 2,2,4-trimethyl-1,3-propanediol (CAS 71839 -38 -8), was negative in a mammalian cell chromosomal aberration test with human lymphocytes at test concentrations up to 5000 ug/mL, either with or without metabolic activation.
Link to relevant study records
- Endpoint:
- genetic toxicity in vitro, other
- Remarks:
- Read across information provided to fulfill endpoints
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- Information taken from a US HPV category of Glycol Esters.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Remarks on result:
- other: The test substance is of low hazard for in vitro genetic toxicity based on adequate information for read-across materials.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The test substance is a member of a category of aliphatic esters submitted by The American Chemistry Council's (ACC) Aliphatic Esters Panel (Panel) under the High Production Volume (HPV) Chemical Challenge Program (ACC, 2003). Information from a Screening Information Data Set (SIDS) developed in that program serves as supplementary or weight-of-evidence in the current dossier. Category ester compounds with similar structures and functionalities were of low potential for mutagenicity. Ames mutagenicity tests are available for the structurally similar substances, heptanoic acid, oxybis(2,1-ethanediyloxy-2,1-ethanediyl) ester (CAS 70729 -40 -9), and heptanoic acid, ester with 2,2,4-trimethyl-1,3-propanediol (CAS 71839 -38 -8). The test substance CAS 70729 -40 -9 was negative in Salmonella strains TA 1535, TA 1537, TA 98 and TA 100, either with or without metabolic activation. The test substance CAS 71839 -38 -8 was also negative in Salmonella strains TA 1535, TA 1537, TA 98 and TA 100, either with or without metabolic activation.
Justification for classification or non-classification
Based on the results of in vitro genetic toxicity testing of structurally similar substances, the test substance would not be classified for mutagenicity according to the European Regulation (EC) No. 1272/2008 on classification and labelling of chemicals.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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