Registration Dossier
Registration Dossier
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EC number: 258-649-2 | CAS number: 53585-53-8
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From June 22 to July 7, 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with few acceptable restrictions. Not fully GLP compliant (no accreditation claimed) but quality system in place.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- yes
- Remarks:
- 14C-radiolabelled material was used; pH not measured; no preliminary study.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- not specified
- Remarks:
- GLP like
- Type of method:
- column elution method
- Water solubility:
- 18 µg/L
- Temp.:
- 20 °C
- pH:
- ca. 7
- Remarks on result:
- other: pH cannot be measured due to the test design. No ionisable group on the molecule.
- Details on results:
- Temperature: 19.9 - 20.1°C.
Two assays were conducted:
Assay 1:
recirculating flow rate 25ml/h
Water solubility: 18.33 µg/L, s = 1.012
Time to attain saturation plateau = 22 hours
Assay 2:
recirculating flow rate 12.5 ml/h
Water solubility: 17.54 µg/L, s = 0.125
Time to attain saturation plateau = 22.5 hours
The difference between assay results was 4.85%. Therefore, assays agreed with a repeatability of less than 30% - Conclusions:
- Interpretation of results: insoluble (< 0.1 mg/L)
The substance was found to be practically insoluble in water. The water solubility was found to be 18 µg/L. - Executive summary:
The water solubility of 14C-radiolabelled dibenzyltoluene was determined according to EU Method A.6 (column elution method). It was found to be 18 µg/L (at 20°C).
Reference
Description of key information
The water solubility of 14C-radiolabelled dibenzyltoluene (Dibenzylbenzene, ar-methyl derivative) was determined according to EU Method A.6 (column elution method). It was found to be 18 µg/L (at 20°C).
Key value for chemical safety assessment
- Water solubility:
- 0.018 mg/L
- at the temperature of:
- 20 °C
Additional information
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