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EC number: 249-033-4 | CAS number: 28462-17-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From May 22th to June 6th, 2019
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- 2008
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1995
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
- Water solubility:
- < 1.08 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 6.98
- Details on results:
- -Preliminary test: the preliminary test at room temperature showed that the water solubility of the test item was below 4.39 mg/l. Therefore the column elution method was performed.
-Main test: the mean value and its standard deviation from five consecutive samples taken from the saturation plateau, each measured twice, were calculated for each run. The mean concentrations calculated on two test using different flows were compared and the repeatability was calculated, which should be better than 30 %. As no signal of the test item could be detected in the fractions, the first column showed a value of the water solubility of <1.08 mg/l (To verify the accuracy of the analytical method freshly prepared standard solutions (prepared with the test item) were measured in between the samples of the column elution method. The recovery rates should liebetween 90 and 110 %. The recovery rate of the measured standard solutions was in the range from 96.1 % to 102.7 %, which shows a good accuracy of
the analytical method.
Following the measurements, the amount of the test item in the columns was checked. For this purpose, columns 1 and 2 were each purged with 100 ml acetone. 0.05 ml of the acetone solutions were diluted to 1 ml with the eluent and measured by HPLC.
These measurements show, that 9.90 mg of the test item could be found in column 1 after the main test, which corresponds to 47.5 % of the starting amount. 10.60 mg of the test item could be found in column 2 after the main test, which corresponds to 50.9 % of the starting amount. In both columns enough test item could be found after the main tests to ensure correct performance of the test. - Conclusions:
- According to OECD Test Guideline 105 (1995) the water solubility at 20°C of the test item was estimated to be below the LOD: cs < 1.08 mg/l.
- Executive summary:
The mean value and its standard deviation from five consecutive samples taken from the saturation plateau, each measured twice, were calculated for each run. The mean concentrations calculated on two tests using different flows were compared and the repeatability was calculated, which should be better than 30 %.
As no signal of the test item could be detected in the fractions, first, second and third columns showed a value of the water solubility of <1.08 mg/l (<LOD).
To verify the accuracy of the analytical metho,d freshly prepared standard solutions were measured in between the samples of the column elution method. The recovery rates should lie between 90 and 110 %. The recovery rate of the measured standard solutions was in the range from 96.1 % to 102.7 %, which shows a good accuracy of the analytical method.
Overall, the water solubility at 20 °C of the test item was estimated to be below the LOD, i.e. < 1.08 mg/l.
Reference
Measurement of standard solutions
Standard solution | Measured value [mg/l] | Recovery rate [ % ] |
(nominal value [mg/l]) | ||
Standard-Ü1 (1.368) | 1.349 | 98.6 |
1.373 | 100.4 | |
1.365 | 99.8 | |
Standard-Ü2 (3.218) | 3.204 | 99.6 |
3.224 | 100.2 | |
3.125 | 97.1 | |
Standard-Ü3 (4.416) | 4.36 | 98.7 |
4.537 | 102.7 | |
Standard-Ü4 (5.066) | 5.04 | 99.5 |
4.868 | 96.1 |
Summarised results of column 1 and 2
Column | Mean concentration | Mean measured concentration | Relative standard deviation (RSD) |
[mg/l] | [mg/l] | [ % ] | |
1 | < 1.08 | < 1.08 | -- |
2 | < 1.08 |
Description of key information
Water solubility at 20 °C was estimated to be below the LOD: cS < 1.08 mg/l.
Key value for chemical safety assessment
- at the temperature of:
- 20 °C
Additional information
OECD guideline 105 (1995).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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