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Diss Factsheets
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EC number: 248-704-9 | CAS number: 27871-49-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- not specified
- Analytical monitoring:
- yes
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- The organism used was the fresh-water crustacean Daphnia magna, cultured in the laboratory under standard conditions, according to the principles of NPR 6503. The animals were less than 24 h old at the beginning of the test.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- None
- Hardness:
- No data
- Test temperature:
- No data
- pH:
- No data
- Dissolved oxygen:
- > 7.5 mg/L
- Salinity:
- Not applicable
- Conductivity:
- No data
- Nominal and measured concentrations:
- Nominal concentrations: No data.
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type (delete if not applicable): open
- Material, size, fill volume: No data
- Aeration: none
- Renewal rate of test solution (frequency/flow rate): none
- No. of organisms per vessel: No data
- No. of vessels per concentration (replicates): No data
- No. of vessels per control (replicates): No data
TEST MEDIUM/WATER PARAMETERS
- Source/preparation of dilution water: No data
OTHER TEST CONDITIONS
- Adjustment of pH: No
- Photoperiod: No data
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): Immobilization at 48 h.
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 1.8 - Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 749 mg/L
- 95% CI:
- >= 592 - <= 788
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- not specified
- Remarks:
- The validity criteria could not be checked due to insufficient documentation.
- Conclusions:
- The 48-h EC50 (immobilization) of methyl-(S)-lactate to Daphnia magna is 749 mg/L.
- Executive summary:
The 48-hr acute toxicity of methyl (S)-lactate to Daphnia magna was studied under static conditions. Test organisms were exposed to control and test chemical at unspecified concentrations for 48 hours. Mortality/immobilization and sublethal effects were observed at test termination. The 48-hour EC50 was 749 mg/L. Information on sublethal effects is not available.
Based on the results of this study, methyl (S)-lactate would not be classified as hazardous to invertebrates in accordance with the classification system of the CLP Regulation.
Results synopsis
Test organism age: No data
Test type: Static
EC50: 749 mg/L (95% C.I.: 663–847 mg/L)
Endpoint(s) effected: Immobilisation
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Qualifier:
- according to guideline
- Guideline:
- other: ECHA guidance on information requirements and chemical safety assessment, chapter R.6: QSARs and grouping of chemicals
- Deviations:
- no
- GLP compliance:
- no
- Specific details on test material used for the study:
- C(=O)(C(C)O)OC
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 811 mg/L
- Remarks on result:
- other: calculated
- Validity criteria fulfilled:
- yes
- Conclusions:
- The EC50 for methyl (S)-lactate was estimated at 811 mg/L, showing very low acute toxicity to invertebrates.
- Executive summary:
For determination of the acute toxicity to invertebrates the 'SciQSAR model for acute toxicity in Daphnia magna (48 h immobilisation, EC50)' as included in the Danish QSAR Database has been applied. Based on the calculated 48-h EC50 value of 811 mg/L it can be concluded that methyl-(S)-lactate shows very low acute toxicity to daphnia, not fulfilling the CLP criterion for environmentally hazardous substances of EC50 ≤ 100 mg/L.
Referenceopen allclose all
Description of key information
The 48-h EC50 value for methyl (S)-lactate for daphnids was predicted to be 811 mg/L. This matches well with an experimental EC50 value of 749 mg/L as reported in the supporting study (Bowmer et al., 1998).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- ca. 811 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.