Bis(ethyl acetoacetato-O1',O3)bis(propan-2-olato)titanium

Ecotoxicological Summary

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:

PNEC aqua (freshwater)

PNEC value:

0.1 mg/L

Assessment factor:

1 000

PNEC freshwater (intermittent releases):

1 mg/L

Marine water

Hazard assessment conclusion:

PNEC aqua (marine water)

PNEC value:

0.01 mg/L

Assessment factor:

10 000

STP

Hazard assessment conclusion:

no emission to STP expected

Sediment (freshwater)

Hazard assessment conclusion:

PNEC sediment (freshwater)

PNEC value:

0.082 mg/kg sediment dw

Extrapolation method:

equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:

PNEC sediment (marine water)

PNEC value:

0.008 mg/kg sediment dw

Extrapolation method:

equilibrium partitioning method

Hazard for air

Air

Hazard assessment conclusion:

no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:

PNEC soil

PNEC value:

0.019 mg/kg soil dw

Extrapolation method:

equilibrium partitioning method

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:

no potential for bioaccumulation

Conclusion on classification

The following reliable data is available for environmental classification of this titanate:

Acute Aquatic Toxicity:

Short-term toxicity to fish:

The 96-h LC50 (mortality) to Leuciscus idus, 275 mg/L based on nominal concentrations (read-across from ethyl acetoacetate; European Chemicals Bureau 2002)

Short term toxicity to invertebrates:

The 48-hour EC50 (immobilisation) to Daphnia magna, > 35 ethyl acetoacetate per litre and > 9.8 mg isopropyl alcohol per litre based on the measured TWA concentrations of the hydrolysis products (OECD 202; Tobor-Kaplon M.A. 2013).

The 48-hour EC50 (immobilisation) to Daphnia magna, > 100 mg/lbased on estimated test item concentrations (OECD 202; Tobor-Kaplon M.A. 2013).

Toxicity to algae:

The 72h-EC50 (growth rate) to Pseudokirchnerella subcapitata, > 42 mg ethyl acetoacetate per litre and > 11 mg isopropyl alcohol per litre; based on the measured TWA concentrations of the hydrolysis products (OECD 201; Tobor-Kaplon M.A. 2013).

The 72h-EC50 (growth rate) to Pseudokirchnerella subcapitata, > 100 mg/lbased on estimated test item concentrations (OECD 201; Tobor-Kaplon M.A. 2013).

The 72h-NOEC (growth rate) toPseudokirchnerella subcapitata, 42 mg ethyl acetoacetate per litre and 11 mg isopropyl alcohol per litre, based on the measured TWA concentrations of the hydrolysis product (OECD 201; Tobor-Kaplon M.A. 2013).

The 72h-NOEC (growth rate) toPseudokirchnerella subcapitata, 100 mg/lbased on estimated test item concentrations (OECD 201; Tobor-Kaplon M.A. 2013).

Conclusion: No acute aquatic toxicity as the lowest of the available toxicity value is > 100 mg/l.  

Degradation:  

Abiotic degradation (hydrolysis): Hydrolytically unstable, Half-life less than 10 minutes @ 25 deg. C (OECD 111)

Main organic decomposition products are non-toxic to aquatic environment and readily biodegradable (isopropyl alcohol; > 70 % at 20-d biodegradation, Price et al. 1974) and the biodegradation of ethyl acetoacetate after 28-d is 66 %. After 7 days, 65 % ethyl acetoacetate was degraded and 10-day window was fulfilled (European Chemicals Bureau 2002).

The aquatic toxicity values (EC50/LC50) of the isopropyl alcohol (IPA) based on the literature are:

Scenedesmus quadricauda, 1800 mg/l in freshwater

Daphnia magna, 6850 mg/l in freshwater

Daphnia magna, >10 000 mg/l in freshwater

Artemia salina, >10000 mg/l in artificial sea water

Pimephales promelas, 9640 mg/L in fresh water

Pimephales promelas,11130 mg/L in lake superior water

Rasbora heteromorpha, 4200 mg/L in fresh water

For ethyl acetoacetate the aquatic toxicity values in the literature are the following:

The 48-h LC50 (mortality) to Leuciscus idus; 275 -575 mg/l (European Chemicals Bureau 2002)

The 24-h EC50 (immobilisation) to Daphnia magna; 790 to 800 mg/l based on nominal test concentrations. LC100 values varied between 1250 to 1136 mg/l, respectively (European Chemicals Bureau 2002).

The 72-h EC50 (growth rate) to Desmodesmus subspicatus; > 500 mg/l based on nominal test concentrations (European Chemicals Bureau 2002).

Conclusion: rapidly degradable.  

Bioaccumulation:

Log Kow for the main degradation products (isopropyl alcohol; 0.05 and ethyl acetoacetate; 0.25). Not possible to determine for the target substance because of rapid hydrolysis.  

Conclusion: No chronic aquatic toxicity as the lowest available toxicity value (72 -h NOEC for algae) for the substance itself is 100 mg/l, substance is rapidly degradable, and the degradation products have low potential for bioconcentration and bioaccumulation.  

Environmental classification:

In accordance with EC Regulation 1272/2008 (CLP):

Not classified as hazardous

In accordance with DSD (Directive 67/548/EEC):

Not classified as hazardous