Bis(ethyl acetoacetato-O1',O3)bis(propan-2-olato)titanium

Hydrolysis

Description of key information

Hydrolytically unstable with the half-life time of < 10 minutes @ 25 deg. C.

Key value for chemical safety assessment

Half-life for hydrolysis:

10 min

at the temperature of:

25 °C

Additional information

Study was performed in accordance with GLP. However, as the substance is highly hydrolytically unstable it was not possible to perform the test as outlined in the guidelines. In order to obtain as much information on hydrolysis as possible, an alternative test was designed.

The hydrolytic stability was tested in buffered aqueous solutions at pH 4.0, 7.0 and 9.0 at 20, 30 and 50 ⁰C for maximum 60 minutes. The progress of hydrolysis was followed by monitoring the main degradation products isopropyl alcohol and ethyl acetoacetate. Additionally, the formation of a white precipitation was observed during the hydrolysis study. This is most likely due to the formation of the insoluble titanium oxides. It was safely concluded that the hydrolysis half-life is ≤ 10 minutes at 25°C.

Based on the Tier 3 approach, no other degradation products were identified. The total response of the hydrolysis products ethyl acetoacetate and isopropyl alcohol was > 99% (area).In the chromatograms, a small additional peak was observed at 4.74 minutes with a response < 1% at the specific mass fragments monitored. This additional peak might derive from an impurity in the test substance or hydrolysis product. To achieve sufficient sensitivity for the analysis of the identified hydrolysis products, selected ion monitoring was used as detection method. Therefore it was not possible to obtain accurate information on the mass fraction of the unknown peak or to record its entire mass spectrum, and hence it was not possible to identify the additional peak. Additionally, the formation of a white precipitation was observed during the hydrolysis study. This is most likely due to the formation of the insoluble titanium oxides.

The results of this study are considered reliable to be used for C&L purposes to conclude this substance to be hydrolytically unstable releasing isopropyl alcohol and ethyl acetoacetate and hydrated titanium dioxide in water. Based on the results this substance can be considered as rapidly degradable.