mecoprop-P (ISO); (R)-2-(4-chloro-2-methylphenoxy)propionic acid

Density

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

02 February 1999 to 22 June 1999

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.3 (Relative Density)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7300 (Density / Relative Density / Bulk Density)

Deviations:

no

GLP compliance:

yes

Type of method:

pycnometer method

Key result

Type:

relative density

Density:

1.31 other: Dimensionless

Temp.:

22 °C

Results

Parameter	Determination 1	Determination 2
w1	14.80069	13.42254
w2	24.49746	23.28851
w3	15.31493	13.92855
w4	24.62874	23.40244
W1	9.69677	9.86597
W2	0.51424	0.50601
W3	9.31382	9.47389
W4	0.38295	0.39208
Vs	0.3837	0.3929
D4^T	1.340	1.288
Mean D4^T	1.31

Conclusions:

Under the conditions of the study the relative density (D4^22 ) of the test material was found to be 1.31.

Executive summary:

The relative density of the test material was assessed according to OECD Test Guideline 109 and EU Method A.4 and in compliance with GLP using a pycnometer method.

A clean, dry pyknometer was accurately weighed (w1) then filled to the limits of its capacity with 0.1 % v/v Tween 80. It was then carefully stoppered without trapping air, dried and re-weighed (w2).

To the clean, dry and accurately weighed pyknometer, test material (approximately 0.5 g) was added. The pyknometer was re-weighed (w3) and then the test material covered with displacement liquid. After vigorous shaking of the stoppered pyknometer, to suspend the test material, air bubbles were removed by ultrasonification (5 minutes). The pyknometer was filled with displacement liquid, stoppered and weighed as before (w4).

Two tests were performed concurrently using separate pyknometers.

Under the conditions of the study the relative density (D4^22) of the test material was found to be 1.31.

Reference 2

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

11 April 1990 to 20 August 1990

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.3 (Relative Density)

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: EPA FIFRA Subdivision D § 63-7

Deviations:

no

GLP compliance:

yes

Type of method:

pycnometer method

Key result

Type:

relative density

Density:

>= 1.281 other: relative

Temp.:

23 °C

Parameter	Determination 1	Determination 2
W1	14.77237	15.37930
W2	15.79728	16.68333
W3	22.63952	23.82390
W4	22.24049	23.31452
W5	24.32685	25.53593
W1	9.55448	10.15663
W2	7.46812	7.93522
W3	1.02491	1.30403
W4	6.84224	7.14057
W5	0.62588	0.79465
ρ1^T	0.78164	0.78128
x̅ ρ1^T	0.78146
Vs	0.80091	1.01688
D4^T	1.27968 (1.280)	1.28239 (1.282)
x̅ D4^T	1.28103 (1.281)

Conclusions:

Under the conditions of the study the mean relative density of the test material is 1.281 at 23 °C.

Executive summary:

The relative density of the test material was assessed according to OECD Method 109, EEC Method A3 and EPA FIFRA Subdivision D § 63 -7 and in compliance with GLP using a pyknometer.

The relative density of the test material was determined relative to distilled water using a pyknometer at 23 °C (296 K). Heavy distillate was employed as the displacing liquid. The temperature of determination was 23 °C. The sample was ground to a fine powder pre-treatment.

Under the conditions of the study the mean relative density of the test material is 1.281 at 23 °C.

Reference 3

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

02 February 1999 to 01 April 1999

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7300 (Density / Relative Density / Bulk Density)

Deviations:

no

GLP compliance:

yes

Type of method:

pycnometer method

Key result

Type:

relative density

Density:

1.3 other: Dimensionless

Temp.:

22 °C

Results

Parameter	Determination 1	Determination 2
w1	14.80058	13.42249
w2	24.50973	23.27521
w3	15.88202	14.42026
w4	24.7534	23.50819
W1	9.70915	9.85272
W2	1.08144	0.99777
W3	8.87138	9.08793
W4	0.83777	0.76479
Vs	0.8394	0.7663
D4^T	1.288	1.302
Average D4^T	1.30

Conclusions:

Under the conditions of the study the relative density (D4^22) of the test material (technical grade) was found to be 1.30.

Executive summary:

The relative density of the test material was assessed according to EPA OPPTS Guideline 830.7300 and in compliance with GLP using a pyknometer method.

A clean, dry pyknometer was accurately weighed (w1) then filled to the limits of its capacity with 0.1 % v/v Tween 80. It was then carefully stoppered without trapping air, dried and re-weighed (w2).

To the clean, dry and accurately weighed pyknometer, test material (approximately 1 g) was added. The pyknometer was re-weighed (w3) and then the test material covered with displacement liquid. After vigorous shaking of the stoppered pyknometer, to suspend the test material, air bubbles were removed by ultrasonification (5 minutes). The pyknometer was filled with displacement liquid, stoppered and weighed as before (w4). Two tests were performed concurrently using separate pyknometers at 22 °C.

Under the conditions of the study the relative density (D4^22) of the test material (technical grade) was found to be 1.30.

Reference 4

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

18 April 1994 to 21 April 1994

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Version / remarks:

12 May 1981

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.3 (Relative Density)

Version / remarks:

December 1992

Deviations:

no

GLP compliance:

yes

Type of method:

air comparison pycnometer (for solids)

Key result

Type:

density

Density:

1.31 g/cm³

Temp.:

20 °C

Key result

Type:

relative density

Density:

1.31 other: Dimensionless

Temp.:

20 °C

The density of the test material was determined using the gas comparison method.

The results of the calibration procedure meet the NOTOX criteria (Va: 86.50 ± 0.15, Vc: 33.50 ± 0.15).

The determination of the density was performed in duplicate.

Temperature of measurements was 20.0 ± 1.0 °C.

Results of the Calibration

A.  Calibration of Va

Calibration volume (Vcyl): 71.13 cm^3

Gas: Helium

Experiment Number	P1 [psig]	P2 [psig)	P3 [psig]	P4 [psig]	Va [cm^3]
1	19.326	12.402	19.503	9.603	86.62

B.  Calibration of the Small Sample Cell

Added volume (Va): 86.62 cm^3

Gas: Helium 

Experiment Number	P5 [psig]	P6 [psig]	Vc [cm^3]
1	19.618	5.483	33.60

 

Determination of the Density of the Test Material (Measurement 1)

Sample mass: 1.7781 g

Added volume (Va): 86.62 cm^3

Cell holder volume (Vc): 33.60 cm^3

Gas: Helium

Experiment Number	P7 [psig]	Pa [psig]	Vp [cm^3]	Density [g/cm^3]
1 2	19.499 19.404	5.290 5.263	1.351 1.362	1.316 1.306
Mean				1.311

Determination of the Density of the Test Material (Measurement 2)

Sample mass: 2.0779 g

Added volume (Va): 86.62 cm^3

Cell holder volume (Vc): 33.60 cm^3

Gas: Helium

Experiment Number	P7 [psig]	Pa [psig]	Vp [cm^3]	Density [g/cm^3]
1 2	19.346 19.376	5.220 5.227	1.591 1.600	1.307 1.300
Mean				1.304

Determination of the Density of the Test Material

Measurement	Density [g/cm^3 ]
1 2	1.311 1.304
Mean	1.308

Conclusions:

Under the conditions of the study the density of the solid test material is 1.31 g/cm^3 (= 1.31 x 10^3 kg/m^3). The relative density (D4^20) is 1.31.

Executive summary:

The density of the test material was assessed according to OECD Test Guideline 109 and in compliance with GLP using a gas comparison pycnometer.

The test cell was pressurised to a pressure of slightly less than 20 psig (1.406 kg/cm^3) and the pressure was read. Subsequently, an extra volume (Va) was added to the pressure system, resulting in a lower pressure, which was read after equilibration of the system.

During the performance of the test, the temperature was measured.

The calibration cell was pressurised, resulting in pressure readings P1 and P2, for the upper and lower pressure readings, respectively.

The volume calibrations were based on a chrome plated calibration cylinder (Vcyl) with a calibrated volume of 71.13 cm^3.

The test procedure was performed, using the calibration cell, containing the calibrated cylinder to obtain pressure readings P3 and P4 for the upper and lower pressure values, respectively.

Pressurisation of the sample cell was performed, resulting in the pressure readings P5 and P6 (upper and lower pressure reading, respectively).

From this, the volume of the sample cell (Vc) was calculated.

The sample cell was weighed, filled with the test material and placed in the stereopycnometer. Then, the test was performed as outlined above, resulting in pressure readings P7 and P8 (upper and lower pressure readings, respectively).

Thereafter the sample cell containing test material was reweighed to determine the mass of the tested test material.

The test procedure as outlined above was repeated using independent test material samples, until reproducible results (deviation in the density ≤ 0.02 g/cm^3 were obtained.

Under the conditions of the study the density of the solid test material is 1.31 g/cm^3 (= 1.31 x 10^3 kg/m^3). The relative density (D4^20) is 1.31.

Reference 5

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

09 September 1994

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

air comparison pycnometer (for solids)

Key result

Type:

density

Density:

1.305 g/cm³

Temp.:

20 °C

Key result

Type:

relative density

Density:

1.305 other: Dimensionless

Temp.:

20 °C

The density of the test sample is 1.305 g/cm^3.

The relative density (D4^20) of the test sample is 1.305

Conclusions:

Under the conditions of the study, the density of the test material is 1.305 g/cm^3 at 20 °C. The relative density (D4^20) is 1.305.

Executive summary:

The density of the test material was assessed according to OECD Test Guideline 109 and in compliance with GLP using an air comparison pycnometer.

Under the conditions of the study, the density of the test material is 1.305 g/cm^3 at 20 °C. The relative density (D4^20) is 1.305.

Reference 6

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

15 December 1993

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

air comparison pycnometer (for solids)

Key result

Type:

density

Density:

1.289 g/cm³

Temp.:

20 °C

Key result

Type:

relative density

Density:

1.289 other: Dimensionless

Temp.:

20 °C

The density of the test sample is 1.289 g/cm^3.

The relative density (D4^20) of the test sample is 1.289.

Conclusions:

Under the conditions of the study the density of the test material is 1.289 g/cm^3. The relative density (D4^20) of the test sample is 1.289

Executive summary:

The density of the test material was assessed according to OECD Test Guideline 109 and in compliance with GLP using an air comparison pycnometer at 20 °C.

Under the conditions of the study the density of the test material is 1.289 g/cm^3.  The relative density (D4^20) of the test sample is 1.289

Reference 7

Endpoint:

bulk density

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

14 December 1003

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Qualifier:

according to guideline

Guideline:

CIPAC MT 186 (Bulk Density)

Deviations:

no

Qualifier:

according to guideline

Guideline:

other: CF/P 041

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

other: Not specified.

Key result

Type:

bulk density

Remarks:

Loose

Density:

714 g/L

Remarks on result:

other: Temperature not specified.

Key result

Type:

bulk density

Remarks:

Tapped

Density:

784 g/L

Remarks on result:

other: Temperature not specified.

Conclusions:

Under the conditions of the study the bulk density of the test material is 714 g/L loose and 784 g/L tapped.

Executive summary:

The bulk density of the test material was assessed according to CIPAC MT 58.4 and in compliance with GLP.

Under the conditions of the study the bulk density of the test material is 714 g/L loose and 784 g/L tapped.

Description of key information

Comb (2000b)

Under the conditions of the study the relative density (D4^22) of the test material was found to be 1.31.

O'Connor (1990)

Under the conditions of the study the mean relative density of the test material is 1.281 at 23 °C.

Comb (2000c)

Under the conditions of the study the relative density (D4^22) of the test material (technical grade) was found to be 1.30.

Van Helvoirt (1994)

Under the conditions of the study the density of the solid test material is 1.31 g/cm^3 (= 1.31 x 10^3 kg/m^3). The relative density (D4^20) is 1.31.

Supporting Study: Kröhl (1994)

Under the conditions of the study, the density of the test material is 1.305 g/cm^3 at 20 °C. The relative density (D4^20) is 1.305.

Supporting Study: Kästel (1994)

Under the conditions of the study the density of the test material is 1.289 g/cm^3.  The relative density (D4^20) of the test sample is 1.289

Supporting Study: Kästel (1994)

Under the conditions of the study the bulk density of the test material is 714 g/L loose and 784 g/L tapped.

Key value for chemical safety assessment

Relative density at 20C:

1.3

Additional information

Comb (2000b)

The relative density of the test material was assessed according to OECD Test Guideline 109 and EU Method A.4 and in compliance with GLP using a pycnometer method. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

A clean, dry pyknometer was accurately weighed (w1) then filled to the limits of its capacity with 0.1 % v/v Tween 80. It was then carefully stoppered without trapping air, dried and re-weighed (w2).

To the clean, dry and accurately weighed pyknometer, test material (approximately 0.5 g) was added. The pyknometer was re-weighed (w3) and then the test material covered with displacement liquid. After vigorous shaking of the stoppered pyknometer, to suspend the test material, air bubbles were removed by ultrasonification (5 minutes). The pyknometer was filled with displacement liquid, stoppered and weighed as before (w4).

Two tests were performed concurrently using separate pyknometers.

Under the conditions of the study the relative density (D4^22) of the test material was found to be 1.31.

O'Connor (1990)

The relative density of the test material was assessed according to OECD Method 109, EEC Method A3 and EPA FIFRA Subdivision D § 63 -7 and in compliance with GLP using a pyknometer. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

The relative density of the test material was determined relative to distilled water using a pyknometer at 23 °C (296 K). Heavy distillate was employed as the displacing liquid. The temperature of determination was 23 °C. The sample was ground to a fine powder pre-treatment.

Under the conditions of the study the mean relative density of the test material is 1.281 at 23 °C.

Comb (2000c)

The relative density of the test material was assessed according to EPA OPPTS Guideline 830.7300 and in compliance with GLP using a pyknometer method. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

A clean, dry pyknometer was accurately weighed (w1) then filled to the limits of its capacity with 0.1 % v/v Tween 80. It was then carefully stoppered without trapping air, dried and re-weighed (w2).

To the clean, dry and accurately weighed pyknometer, test material (approximately 1 g) was added. The pyknometer was re-weighed (w3) and then the test material covered with displacement liquid. After vigorous shaking of the stoppered pyknometer, to suspend the test material, air bubbles were removed by ultrasonification (5 minutes). The pyknometer was filled with displacement liquid, stoppered and weighed as before (w4). Two tests were performed concurrently using separate pyknometers at 22 °C.

Under the conditions of the study the relative density (D4^22) of the test material (technical grade) was found to be 1.30.

Van Helvoirt (1994)

The density of the test material was assessed according to OECD Test Guideline 109 and in compliance with GLP using a gas comparison pycnometer. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).

The test cell was pressurised to a pressure of slightly less than 20 psig (1.406 kg/cm^3) and the pressure was read. Subsequently, an extra volume (Va) was added to the pressure system, resulting in a lower pressure, which was read after equilibration of the system.

During the performance of the test, the temperature was measured.

The calibration cell was pressurised, resulting in pressure readings P1 and P2, for the upper and lower pressure readings, respectively.

The volume calibrations were based on a chrome plated calibration cylinder (Vcyl) with a calibrated volume of 71.13 cm^3.

The test procedure was performed, using the calibration cell, containing the calibrated cylinder to obtain pressure readings P3 and P4 for the upper and lower pressure values, respectively.

Pressurisation of the sample cell was performed, resulting in the pressure readings P5 and P6 (upper and lower pressure reading, respectively).

From this, the volume of the sample cell (Vc) was calculated.

The sample cell was weighed, filled with the test material and placed in the stereopycnometer. Then, the test was performed as outlined above, resulting in pressure readings P7 and P8 (upper and lower pressure readings, respectively).

Thereafter the sample cell containing test material was reweighed to determine the mass of the tested test material.

The test procedure as outlined above was repeated using independent test material samples, until reproducible results (deviation in the density ≤ 0.02 g/cm^3 were obtained.

Under the conditions of the study the density of the solid test material is 1.31 g/cm^3 (= 1.31 x 10^3 kg/m^3). The relative density (D4^20) is 1.31.

Supporting Study: Kröhl (1994)

The density of the test material was assessed according to OECD Test Guideline 109 and in compliance with GLP using an air comparison pycnometer. The study was awarded a reliability score of 2 in accordance with the criteria set forth by Klimisch et al. (1997).

Under the conditions of the study, the density of the test material is 1.305 g/cm^3 at 20 °C. The relative density (D4^20) is 1.305.

Supporting Study: Kästel (1994)

The density of the test material was assessed according to OECD Test Guideline 109 and in compliance with GLP using an air comparison pycnometer at 20 °C. The study was awarded a reliability score of 2 in accordance with the criteria set forth by Klimisch et al. (1997).

Under the conditions of the study the density of the test material is 1.289 g/cm^3.  The relative density (D4^20) of the test sample is 1.289

Supporting Study: Kästel (1994)

The bulk density of the test material was assessed according to CIPAC MT 58.4 and in compliance with GLP. The study was awarded a reliability score of 2 in accordance with the criteria set forth by Klimisch et al. (1997).

Under the conditions of the study the bulk density of the test material is 714 g/L loose and 784 g/L tapped.