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Diss Factsheets
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EC number: 235-402-7 | CAS number: 12217-80-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Principles of method if other than guideline:
- None
- GLP compliance:
- yes
- Specific details on test material used for the study:
- None
- Analytical monitoring:
- yes
- Details on sampling:
- Not available
- Vehicle:
- yes
- Details on test solutions:
- In each test concentration and controls 20 Daphnia were tested, divided into four groups of five animals each in 50 ml test medium in a glass-beaker (100 ml). The test was performed in an air-conditioned room.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- The study was performed with young Daphnia magna Straus (6-24 hours old), bred in the laboratories of RCC under standardized conditions. The parental Daphnia were maintained in the same reconstituted water as in the test for at least 24 hours prior to the start of the test.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Post exposure observation period:
- None
- Hardness:
- 2.5 mmol/L as CaCO3
- Test temperature:
- 18.0 - 19.5 °C
- pH:
- None
- Dissolved oxygen:
- None
- Salinity:
- 0.8 mmol/L
- Nominal and measured concentrations:
- The final nominal concentrations were: 0.04, 0.20, 0.40, 2.0 and 4.0 mg test substance/L, a control without any additions and a solvent control ( 0.1 ml Dimethylformamid per 1 test medium).
- Details on test conditions:
- None
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- In the controls no immobility or mortality of the test animals was observed.
- Results with reference substance (positive control):
- None
- Reported statistics and error estimates:
- None
- Validity criteria fulfilled:
- yes
- Conclusions:
- The NOEC (highest concentration tested without toxic effect) of FAT 36'152/D was determined to be 4.0 mg/L or higher.
- Executive summary:
Short term toxicity of FAT 36152/D to Daphnia magna was determined in a 48-hour static test conducted according to the OECD Guideline for Testing of Chemicals, Section 2, No. 202, adopted 4 April 84. The test was performed in compliance with the Good Laboratory Practice Regulations. The nominal concentrations tested were 0.04, 0.20, 0.40, 2.0 and 4.0 mg test substance/L, a solvent control group and a control without any additions. In the control no immobility or mortality of the test animals was observed.
FAT 36'152/D had no acute toxic effect on Daphnia magna during the test duration of 48 hours up to the highest concentration tested of 4.0 mg test substance/l (as the highest concentration that was possible to dissolve in dimethylformamid p.A. at room temperature and an addition of 100 µL solvent stock solution to 1 L test medium). Therefore, the NOEC (highest concentration tested without toxic effect) of FAT 36152/D was determined to be 4.0 mg/L or higher. The 48 h EC50 could not be specified. The test substance could be detected only in a sample of the analysed test media of the highest concentration tested of 4.0 mg/L, but also in this concentration the recovery rate was low (2.8 % of the nominal value). In samples of the lower test concentrations the test substance was not detectable. Due to the fact that the test substance is not soluble in water, it obviously precipitated and homogeneous samples for the analytical measurements could not be taken. Since the measured concentration in the stock solution amounted to 98.8 % of the nominal value, the reported results are related to the nominal concentrations of the test substance.
Reference
Influence of FAT 36152/D on the motility of Daphnia magna:
Nominal Conc. Of test material (mg/l) | No. of Daphnia tested | No. of immobilixzed Daphnia after: | % of immobilized Daphnia after: | ||
24 h | 48 h | 24 h | 48 h | ||
Control | 20 | 0 | 0 | 0 | 0 |
Solvent control | 20 | 0 | 0 | 0 | 0 |
0.04 | 20 | 0 | 0 | 0 | 0 |
0.2 | 20 | 0 | 0 | 0 | 0 |
0.4 | 20 | 0 | 0 | 0 | 0 |
2 | 20 | 0 | 3 | 0 | 15 |
4 | 20 | 0 | 0 | 0 | 0 |
Dissolved oxygen concentrations (mg/l) and pH-values in the test media at the start and end of the acute toxicity test with Daphnia magna:
Nominal Conc. Of test material (mg/l) | Start (0 hour) | End (48 hours) | ||
Oxygen | pH | Oxygen | pH | |
Control | 9 | 8 | 8.5 | 7.7 |
Solvent control | 9.3 | 8 | 8.8 | 7.5 |
0.04 | * | * | 9 | 7.5 |
0.2 | * | * | 9 | 7.5 |
0.4 | * | * | 9 | 7.5 |
2 | * | * | 9 | 7.5 |
4 | 9.1 | 8 | 9 | 7.5 |
Description of key information
The EC50 was higher than 4 mg/l after 48 hours exposure.
Key value for chemical safety assessment
Additional information
Short term toxicity of FAT 36152/D to Daphnia magna was determined in a 48-hour static test according to the OECD Guideline for Testing of Chemicals, Section 2, No. 202, adopted 4 April 84. The nominal concentrations tested were 0.04, 0.20, 0.40, 2.0 and 4.0 mg test substance/L, a solvent control group and a control without any additions. In the control no immobility or mortality of the test animals was observed. FAT 36'152/D had no acute toxic effect on Daphnia magna during the test duration of 48 hours up to the highest concentration tested of 4.0 mg test substance/l (as the highest concentration that was possible to dissolve in dimethylformamid p.A. at room temperature and an addition of 100 µLsolvent stock solution to 1 L test medium). Therefore, the NOEC (highest concentration tested without toxic effect) of FAT 36152/D was determined to be 4.0 mg/L or higher.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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