Registration Dossier
Registration Dossier
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EC number: 233-593-1 | CAS number: 10254-57-6
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
The 72-Hour EC50 of methylenbis(dibutyldithiocarbamate) (centrifuged test media) to Scenedesmus subspicatus is greater than 0.0325 mg/L (mean measured) and correspondingly the NOEC was 0.0325 mg/L (Safepharm Laboratories, 2004).
The test material is known to possess a low water solubility (0.243 mg/l at 20 ± 5 ºC). In the absence of any evidence of toxicity, and taking into consideration the difficulties in water solubility, it is considered that no evidence of toxicity is seen at the limit of solubility.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 0.033 mg/L
- EC10 or NOEC for freshwater algae:
- 0.033 mg/L
Additional information
In an OECD 201 study, conducted to GLP, the 72-Hour EC50 of methylenbis(dibutyldithiocarbamate) (centrifuged test media) toScenedesmus subspicatus is greater than 0.0325 mg/L (mean measured) and correspondingly the NOEC was 0.0325 mg/L (Safepharm Laboratories, 2004).
No mortality was observed during the test. The test was conducted using dimethylforamide to pre-dissolve the test material before delusion in test media. When analysed test concentrations were far lower than what was theoretically created, indicating that there were difficulties stemming from water solubility of the test material. The test material is known to possess a low water solubility (0.243 mg/l at 20 ± 5 ºC). In the absence of any evidence of toxicity, and taking into consideration the difficulties in water solubility, it is considered that no evidence of toxicity is seen at the limit of solubility.
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