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Diss Factsheets
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EC number: 227-105-6 | CAS number: 5657-17-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic plants other than algae
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic plants other than algae
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- no data available
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable, well documented study
- Justification for type of information:
- Study is read across and slightly updated and presented under "type of information" as experimental study until the lead company has updated the Source RSS
Read across justification is presented in IUCLID chapter 13 - Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 221 (Lemna sp. Growth Inhibition Test)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Lemna minor
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 7 d
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The growth of Lemna minor was affected by pH. In test sets supplemented with EDTA between 40 und 200 µM concentrations, growth inhibition was observed in the test medium with adjusted pH of 7.0 at EDTA concentration of 100 µM and higher.
- Executive summary:
The growth of Lemna minor was determined after 7 days of exposure. Based on the results growth of duckweed was affected by pH. In test sets supplemented with EDTA between 40 und 200 µM concentrations, growth inhibition was observed in the test medium with adjusted pH of 7.0 at EDTA concentration of 100 µM and higher.
Reference
Effects of pH and EDTA on the relative growth rate of Lemna minor
pH-value |
Concentration of EDTA (µM/L) |
||||
0 |
40 |
80 |
100 |
200 |
|
5.0 |
12.6 |
12.6 |
15.8 |
19.4 |
19.8 |
6.0 |
12.3 |
11.9 |
14.8 |
15.8 |
15.7 |
7.0 |
15.5 |
18.9 |
15.2 |
13.0 |
10.2 |
Description of key information
No data on Toxicity to aquatic plants other than algae is available for H2 ED2A. Consistent with the other ecotoxicity endpoints, the available data from H4 EDTA are read-across to fill the datagap. For justification of the read-across see IUCLID 6, Chapter 13.
The toxicity of H4 EDTA on the duckweed Lemna minor has been evaluated according to a guideline which is equivalent to OECD TG 221.
The growth of Lemna minor was quantified after 7 days of exposure. Based on the results growth of duckweed was affected by pH. In test sets supplemented with EDTA between 40 und 200 µM concentrations, growth inhibition was observed in the test medium with adjusted pH of 7.0 at EDTA concentration of 100 µM and higher.
Key value for chemical safety assessment
- EC10 or NOEC for freshwater plants:
- 29.2 mg/L
Additional information
No data on Toxicity to aquatic plants other than algae is available for ED2A-H2. Consistent with the other ecotoxicity endpoints, the available data from EDTA are read-across to fill the datagap. For justification of the read-across see IUCLID 6, Chapter 13.
The toxicity of H4 -EDTA on the duckweed Lemna minor has been evaluated according to a guideline which is equivalent to OECD TG 221.
The growth of Lemna minor was quantified after 7 days of exposure. Based on the results growth of duckweed was affected by pH. In test sets supplemented with EDTA between 40 und 200 µM concentrations, growth inhibition was observed in the test medium with adjusted pH of 7.0 at EDTA concentration of 100 µM and higher.
It should be noted that the culture medium used in this test for Lemna minor is like the OECD culture medium for algae a minimal medium which means that H4 -EDTA like ED2A-H2 can reduce the bioavailability of essential micronutrients in the culture medium to a level where growth is limited. This indirect nutrient deficiency effect is an artefact and should not be used for the effect assessment because it is unlikely to occur in the environment (see Guidance on Hazard to the Aquatic Environment Globally Harmonized System GHS Annex 9 A9.3.3.4, 2007).
This was indicated by the results of this study. Data revealed that growth were dependent on the concentration of EDTA and pH.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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