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EC number: 216-676-7 | CAS number: 1638-86-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral:LD50 > 2000mg/kg
Inhalation: 2/6 animals died after either 4 or 7h exposure to the saturated vapour concentration
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Version / remarks:
- 1992-12-29
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomas GmbH, Biberach, FRG
- Age at study initiation: young adult animals
- Weight at study initiation: 150 g - 300 g (+/- 20% of the mean weight)
- Fasting period before study: 16 h
- Housing: single housing
- Diet: Kliba-Labordiät 343, Klingentalmuehle AG Kaiseraugst.,Switzerland, ad libitum
- Water: tap water ad libitum
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C):20-24
- Humidity (%):30-70
- Photoperiod (hrs dark / hrs light): 12/12 - Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 10 and 40 g /100mL
CLASS METHOD
- Rationale for the selection of the starting dose: based on the physical and chemical characteristics of the substance and the composition a starting dose of 500 mg/kg body weight has been chosen with 3 male and 3 female animals. As no mortality ocured, 2000 mg/kg body weight were tested with 3 male and 3 female rats. - Doses:
- 500 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weighing shortly before application (day 0), weekly thereafter and at the end of the study, recording of signs and symptoms severals times on the day of administration, at least once each workday for the individual animals
- Necropsy of survivors performed: yes - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- other: One female animal of the high dose group: impaired general state, dyspnea, apathy, abdominal position, staggering, ataxia. The animal appeared normal one day after administration
- Gross pathology:
- Nothing abnormal detected
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- Comparable to current guideline requirements and scientifically valid.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable study report, only 6 animals tested instead of 10 as requested in the guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- 1981-05-12
- Deviations:
- yes
- Remarks:
- 6 animals tested instead of 10
- Principles of method if other than guideline:
- The study procedure was based on the OECD Guidelines, Method 403, 1981 and the "range-finding toxicity test" published by H.F. Smyth et al., 1962.
- GLP compliance:
- yes
- Remarks:
- but no QAU audit of the report performed
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. K. Thomae GmbH, Biberach, FRG)
- Age at study initiation: 8-9 weeks
- Weight at study initiation: females: 190,6g +/- 7,4 g, males: 267,6g +/- 12,9 g
- Housing: single housing, DK III Becker cages, without bedding
- Diet: KLIBA laboratory diet 10 mm pellets, Klingentalmühle AG, Kaiseraugst, Switzerland, ad libitum
- Water: ad libitum
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C):20-24
- Humidity (%):30-70
- Photoperiod (hrs dark / hrs light): 12/12 - Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: glass generator containing product placed in a waterbath (20 °C), a stream of 200 L/h compressed air was bubbled through the the substance column, the inhalation atmosphere was passed through a downstream mixing chamber and a glass distributor to 6 glass tubes containing the animals
- Method of conditioning air: replacing generator after 30 minutes
- Temperature, humidity, pressure in air chamber: 19-25 °C
TEST ATMOSPHERE
- Brief description of analytical method used: The amount of test substance consumed was determined by reweighing the generators. The nominal concentration was calculated from the amount of test substance consumed and the total air volume used. - Analytical verification of test atmosphere concentrations:
- no
- Remarks on duration:
- 4 and 7 hours
- Concentrations:
- 0.5 mg/L nominal (saturated vapour concentration = 0.32mg/L)
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: body weights of surviving animals were determined prior to exposure, after 7 days and at the end of the observation period. A check for overt clinical signs of toxicity or mortality as well as a check for feed and drinking water was made twice a day.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: gross-pathological examination of all animals - Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 0.32 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: saturated vapour concentration
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 0.32 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 7 h
- Remarks on result:
- other: saturated vapour concentration
- Mortality:
- 7-hour exposure and 4-hour exposure: 2/6 animals in each experiment
- Clinical signs:
- other: The animals which were exposed for 4 h showed attempts to escape, irregular and accelerated respiration, respiratory sounds, squatting posture and piloerection. In the animals exposed for 7 h apathy was observed additionally. No clinical symptoms were obs
- Body weight:
- Body weight development was decreased in the first post exposure week, but recovered in the second in both exposure groups.
- Gross pathology:
- During necropsy, agonal congestive hyperemia and focal dark red discoloration of the lungs was observed in the animals that died.
The animals examined at termination of the study showed no abnormalities. - Interpretation of results:
- toxic
- Remarks:
- Migrated information
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- discriminating conc.
- Value:
- 0.32 mg/m³ air
- Quality of whole database:
- scientifically valid but deviant from guideline concerning the amount of test animals
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Oral:
The study on the acute oral toxicity in rats was performed to asses the acute toxicity following oral administration of the test substance, applied as a solution in olive oil DAB 10, in Wistar rats. The study was based on the EU guideline B1 and modified according to the acute toxic class method. To two groups each of six fasted animals (three males and three females) a single oral dose of the test material preparation in olive oil DAB 10 at dose levels of 2000 mg/kg and 500 mg/kg body weight was given.
Signs of toxicity noted in 1 female animal of the 2000 mg/kg dose group were impaired general state, dyspnoea, apathy, abdominal position, staggering and ataxia. The animal appeared normal 1 day after application.
The expected body weight gain was generally observed in the course of the study.
No mortality occured.
No abnormalities were noted at necropsy of animals sacrificed at the end of the study.
Under the condtions of the study the median lethal dose of the test substance after oral application was found to be greater than 2000 mg/kg body weight for the male and female animals.
Inhalation:
In an inhalation hazard test groups of 3 male and 3 female Wistar rats were exposed to a nominal concentration of about 0.5 mg/L as determined by weight difference of the test substance container prior and after the exposure period (saturated vapor concentration calculated from extrapolated vapor pressure at 20°C is 0.32 mg/L). After 4 and 7 hours 2/6 and 2/6 animals died, respectively. The animals which were exposed for 4h showed attempts to escape, irregular and accelerated respiration, respiratory sounds, squatting posture and piloerection. In the animals exposed for 7 h apathy was observed additionally. No clinical symptoms were observed from post exposure day 7 onwards in either test group. Body weight development was decreased in the first post exposure week but recovered in the second in both exposure groups.
During necropsy, agonal congestive hyperemia and focal dark red discoloration of the lungs was observed in the animals that died. The animals examined at termination of the study showed no abnormalities.
From this study it can be concluded that the 4 - and 7- hour-LC50 of the test substance is above the saturated vapour concentration at room temperature (about 0.32 mg/L). Because less than 50% of the animals died, and the nominal concentration based on weight difference was 0.5mg/L (i.e. somewhat higher exposure might have occured), classification in category 2 according to GHS is proposed.
Justification for selection of acute toxicity – oral endpoint
only one reliable GLP and guideline study available
Justification for selection of acute toxicity – inhalation endpoint
only one study available
Justification for classification or non-classification
Based on the results of the acute oral toxicity study and the acute inhalation study, Diethoxyphenlyphosphin needs to be regarded as toxic after inhalation (R23 according to Directive 67/548/EEC (DSD) and Cat. 2 according to Regulation (EC) No 1272/2008 (CLP).
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