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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1978
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study performed prior to international guidlines and no information on GLPs. Study is well reported.
Principles of method if other than guideline:
Designed to conform to the then-most-recent draft of the Guidelines for Registering pesticides in the United States (Jan 30, 1978). Krezeminiski et al. (1975. J Agr food Chem 23:1060) and Schultz (1973. J Agr Food Chem 21:186) were used as guides.
GLP compliance:
not specified
Radiolabelling:
yes
Details on sampling:
Water sampled daily. Fish sampled on Rx days 1,3,7,10,14,21, 28 and Withdrawal days 1, 3, 7, 10 and 14.
Vehicle:
yes
Details on preparation of test solutions, spiked fish food or sediment:
Stock concentration 16.91 ppm
Solvent Carrier 10% Acetone-water
Aquaria final concentration 0.01 ppm
Test organisms (species):
Lepomis macrochirus
Details on test organisms:
Fish suplied by alex Fish Co., San Rafael, CA. Conditioned for 14 d prior to treatment. 05 - 2.0 g.
Route of exposure:
aqueous
Test type:
flow-through
Water / sediment media type:
natural water: freshwater
Total exposure / uptake duration:
28 d
Total depuration duration:
14 d
Reference substance (positive control):
no
Details on estimation of bioconcentration:
See above.
Type:
BCF
Value:
0
Basis:
edible fraction
Remarks on result:
other: Concentration (ppm) in tissue at all timepoints was <0.01 ppm
Type:
BCF
Value:
0
Basis:
non-edible fraction
Remarks on result:
other: Concentration in tissue at all time points was <0.01 ppm.

Results of TBPA bioconcentration study in fish.

Interval (d)

[Tetrabromophthalic anhydride; ppm]

Treatment

Water

Fish

Edible

Viscera

1

0.010

<0.01

<0.01

3

0.010

<0.01

<0.01

7

0.008

<0.01

<0.01

10

-

<0.01

<0.01

14

0.011

<0.01

<0.01

21

0.009

<0.01

<0.01

28

0.011

<0.01

<0.01

Withdrawal

1

0.002

<0.01

<0.01

3

ND

<0.01

<0.01

7

ND

<0.01

<0.01

10

ND

<0.01

<0.01

14

ND

<0.01

<0.01

Validity criteria fulfilled:
yes
Conclusions:
TBPA was not bioaccumulated by fish (BCF=0).
Executive summary:

The mean concentration of TBPA in water, based on liquid scintillation counting of 14C-activity, during the treatment phase was 0.0098 +/- 0.001 ppm. This level was reached within 2 days after initiation. Combustion analysis of fish samples collected during the treatment and withdrawal phases indicate that the test artical was not accumulated by the fish (BCF=0).

The method of analysis would detect any 14C-activity derived from the test substance, including parent molecule, metabolites and hydrolysis products (e.g. TBPA-acid).

Results of TBPA bioconcentration study in fish.

Interval (d)

[Tetrabromophthalic anhydride; ppm]

Treatment

Water

Fish

Edible

Viscera

1

0.010

<0.01

<0.01

3

0.010

<0.01

<0.01

7

0.008

<0.01

<0.01

10

-

<0.01

<0.01

14

0.011

<0.01

<0.01

21

0.009

<0.01

<0.01

28

0.011

<0.01

<0.01

Withdrawal

1

0.002

<0.01

<0.01

3

ND

<0.01

<0.01

7

ND

<0.01

<0.01

10

ND

<0.01

<0.01

14

ND

<0.01

<0.01

Description of key information

TBPA was not bioaccumulated by fish (BCF=0).

Key value for chemical safety assessment

BCF (aquatic species):
0 dimensionless

Additional information