Registration Dossier
Registration Dossier
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EC number: 205-503-0 | CAS number: 141-82-2
Toxicity to microorganisms
Administrative data
- Endpoint:
- toxicity to microorganisms, other
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance is found to be readily biodegradable and the applied test concentrations are in the range of concentrations that can be expected in the influent of a sewage treatment plant
Cross-reference
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
- Endpoint:
- biodegradation in water: screening test, other
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- Up to 20 days
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Based on peer reviewed research into methods to determine biodegradation
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method C.5 (Degradation: Biochemical Oxygen Demand)
- Principles of method if other than guideline:
- Measurement of oxygen levels and TOCMeasurement of bacterial growth as indicator of biodegradation
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- Metropolitan sewer
- Duration of test (contact time):
- 20 d
- Initial conc.:
- ca. 10 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- Sampling day 0, 1, 2, 3, 4, 5, 7, 9, 12, 16, 20
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- ca. 89
- Sampling time:
- 5 d
- Details on results:
- BOD5 = 0.16 mg/mg
- Key result
- Parameter:
- BOD5
- Value:
- 16 g O2/g test mat.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The test substance mineralised within 5 days and no lag time reported.It is conclused that the substance is readily biodegradable, meeting the 10d-window
- Executive summary:
Oxalic acid is seen as a suitable surrogate for malonic acid.
No lag time was reported with immediate start to degradation processes
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
