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EC number: 202-496-6 | CAS number: 96-29-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: inherent biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This is an older study was conducted at an reputable laboratory with known expertise in this type of testing. Sufficient details were available to assess the biodegradation of the test substance
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 302 B (Inherent biodegradability: Zahn-Wellens/EMPA Test)
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, industrial (adaptation not specified)
- Duration of test (contact time):
- ca. 18 d
- Initial conc.:
- ca. 400 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- DOC removal
- Reference substance:
- other: not reported
- Parameter:
- % degradation (DOC removal)
- Value:
- ca. 35
- Sampling time:
- 5 d
- Parameter:
- % degradation (DOC removal)
- Value:
- ca. 51
- Sampling time:
- 8 d
- Parameter:
- % degradation (DOC removal)
- Value:
- ca. 70
- Sampling time:
- 18 d
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- inherently biodegradable
- Conclusions:
- Methyl ethyl ketoxmime was inherently biodegradable in this 18-day test.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The test parameters evaluated in this study are expected to be well documented and scientifically acceptable. However, the study is considered valid with restriction due to use of a 21-day test rather than a 28 day test, and because it was not conducted according to GLP.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- GLP compliance:
- not specified
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- - Concentration of sludge: 100 mg/L (as suspended solid)
- Duration of test (contact time):
- <= 21 d
- Initial conc.:
- ca. 30 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- other: BOD, TOC and gas chromatography after 21 days
- Details on study design:
- TEST CONDITIONS
- Test temperature: 25 degrees C - Reference substance:
- aniline
- Parameter:
- other: BOD
- Value:
- ca. 14.5
- Sampling time:
- 21 d
- Parameter:
- % degradation (TOC removal)
- Value:
- ca. 27
- Sampling time:
- 21 d
- Details on results:
- - Degree of biodegradation was 14.5% by BOD after 21 days.
- Degradation by total organic carbon (TOC) was 27% (average of 19 and 34%) after 21 days.
- Degradation by GC analysis was 27% (average of 21 and 31%) after 21 days.
- No degradation products were detected by GC chromatogram at the end of the test - Validity criteria fulfilled:
- not specified
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- Methyl ethyl ketoxime is exhibited some biodegradation but did not meet the criteria to be considered readily biodegradable based on the results of this 21-day test.
Referenceopen allclose all
Description of key information
MEKO is not readily biodegradable based on a modified MITI test, but is inherently biodegradable based on an OECD Guideline 302B test. In the assessment MEKO is characterised as “Inherently biodegradable, not fulfilling specific criteria”.
Key value for chemical safety assessment
- Biodegradation in water:
- inherently biodegradable, not fulfilling specific criteria
- Type of water:
- freshwater
Additional information
In a modified MITI test for ready biodegradation (METI, 1976), 14.5% degradation was observed after 21 days, based on BOD. Degradation by total organic carbon (TOC) was 27% (average of 19 and 34%) after 21 days. Degradation by GC analysis was 27% (average of 21 and 31%) after 21 days. Based on these results, MEKO is not readily biodegradable. In an OECD Guideline 302B (inherent biodegradability) test (BASF, 1978), 35% biodegradation was observed after 5 days, 51% after 8 days and 70% degradation was observed after 14 days, based on DOC removal. Thus the substance is inherently biodegradable but does not fulfil specific criteria (≥70 % mineralisation (DOC removal) within 7 d).
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