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EC number: 201-236-9 | CAS number: 79-94-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
96 h NOEC 5.6 mg/L (Pseudokirchneriella subcapitata)
Key value for chemical safety assessment
- EC10 or NOEC for freshwater algae:
- 5.6 mg/L
Additional information
In the key study, the potential of TBBPA to affect the freshwater algae S. capricornutum (new name Pseudokirchneriella subcapitata) was investigated in a 96 h test. 14C-TBBPA fortified with unlabelled test article was added to freshwater at nominal concentrations of 0, 0.60, 1.2, 2.4, 4.8, and 9.6 mg/L. An inoculum of S. capricornutum cells sufficient to provide 1 x 10E4 cells/mL was aseptically introduced to each vessel. Cell counts were made at 24 h intervals.
Mean measured 14C-activity indicated TBBPA concentrations averaged 61% of nominal at time 0 and 96 h, and were reported to be 0, 0.34, 0.76, 1.5, 3.0, and 5.6 mg/L (average of 0 and 96 h values). Analysis of the high dose via HPLC indicated concentrations substantially below that of radiometric value (0.55 mg/L versus 5.1 and 6.1 mg/L in the 0 and 96 h samples). The report concludes the difference was due inclusion of fine particulate matter (e.g. undissolved TBBPA) in the radiometric value, which was excluded on the HPLC column. Based on this, the report concluded the true water solubility of TBBPA was approximately 0.55 mg/L, and that all of the tested TBBPA concentrations were at or above TBBPA's water solubility.
Algal cell counts performed at 24, 48, 72 and 96 h indicated no effect of TBBPA at any dose. The 96 h NOEC in freshwater algae was ≥5.6 mg/L (measured), which was above TBBPA's water solubility.
Supporting information is provided in the form of a study in which the toxicity of the test material to three species of marine algae was investigated in test conducted in accordance with sound scientific principles. Marine unicellular algae were exposed to industrial brominated compounds in six algal growth media. The toxicity test method was similar to that of Walsh and Alexander (1980).
Skeletonema costatum, Thalassiosira pseudonana and Chlorella sp. were exposed to the test material in six salt water media for 72, 72 and 96 hours, respectively (salinity 30 parts per thousand). The test material was introduced into growth flasks by adding 0.05 mL test material in nanograde acetone to 51 mL growth medium with algae. Toxicity was expressed as the EC50 based upon cell numbers after incubation for 72 hours.
Under the conditions of the study, Chlorella sp. was not inhibited by as much as 50 % by 1.5 mg/L test material and the test material was toxic to S. costatum and T. pseudonana below the estimated saturation concentration (1.5 mg/litre).
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