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Diss Factsheets
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EC number: 201-236-9 | CAS number: 79-94-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dissociation constant
Administrative data
Link to relevant study record(s)
Description of key information
Dissociation constant.001: pKa values calculated for organic phase samples at pH 9.5 and 10.0 were 9.37 and 9.43, respectively, with a mean pKa of 9.40 and a mean Ka of 3.98 x 10^-10.
Dissociation constant.002: The pKa values of TBBPA are reported in a WHO document to be 7.5 and 8.5.
Key value for chemical safety assessment
- pKa at 20°C:
- 9.4
Additional information
In a GLP/Guideline-compliant study (Dissociation constant.001),the dissociation constant (pKa) of TBBPA was determined to be 9.40.
The direct titration method typically used for determining the dissociation constant K was not suitable for TBBPA due to its extremely low aqueous solubility. An alternative method developed at the testing facility was employed. The test substance was purified by normal phase HPLC with fraction collection to obtain the purest available form of the test material as specified in the guideline. Test solutions, each containing 50 µg/L nominal concentration of TBBPA, were prepared over the pH range 6.0 to 12.0 at 0.5 pH intervals.
Both the dissociated and undissociated components of TBBPA were determined for each test solution by HPLC with ultraviolet detection.
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