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Diss Factsheets
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EC number: 200-909-4 | CAS number: 75-86-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
No studies regarding the carcinogenic potential of 2-hydroxy-2-methylpropionitril were located in the available literature.
Under physiological conditions, 2-hydroxy-2-methylpropionitrile decomposes to yield its molar equivalent in hydrogen cyanide (HCN) and acetone.
Carcinogenicity studies performed on HCN and acetone gave no evidence on intrinsic carcinogenic activity of these degradation products at all.
Genetic toxicity studies with 2-hydroxy-2-methylpropionitril were generally negative, as well as genetic toxicity studies performed with HCN, HCN salts and acetone (see chapter 7.6).
In conclusion, there is no indication on intrinsic carcinogenic activity of 2 -hydroxy-2 -methylpropionitril.
Key value for chemical safety assessment
Justification for classification or non-classification
There is no evidence on intrinsic carcinogenic activity of 2-hydroxy-2-methylpropionitrile. Thus 2-hydroxy-2-methylpropionitrile does not comply with the classification requirements regarding carcinogenicity outlined in regulation (EC) 1272/2008 or the former directive on classification and labelling 67/548/EWG.
Additional information
No studies regarding the carcinogenic potential of 2-hydroxy-2-methylpropionitril were located in the available literature.
Under physiological conditions, 2-hydroxy-2-methylpropionitrile decomposes to yield its molar equivalent in hydrogen cyanide (HCN) and acetone. Carcinogenicity studies performed on hydrogen cyanide and acetone gave no evidence on intrinsic carcinogenic activity of these degradation products at all: "No cancers were induced in rats in a two-year feeding study with HCN" (quotation taken from rationale for AEGL (Acute Exposure Guideline Levels) established by the AEGL-COMMITTEE (US-NAC, Acetone Cyanohydrin, Interim Acute Exposure Guideline Levels (AEGLs), Interim final draft, 2005). "Lifetime dermal carcinogenicity studies in mice treated with up to 0.2 mL of acetone did not reveal any increase in organ tumor incidence relative to untreated control animals" (quotation taken from SIDS Initial Assessment Report on Acetone, OECD UNEP Publications, 1999).
Genetic toxicity studies with 2-hydroxy-2-methylpropionitril were generally negative, as well as genetic toxicity studies performed with HCN, HCN alkali salts and acetone (see chapter 7.6).
In conclusion, there is no indication on intrinsic carcinogenic properties of 2 -hydroxy-2 -methylpropionitril.
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