Registration Dossier
Registration Dossier
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EC number: 200-681-6 | CAS number: 68-22-4
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- - Batch No.: 12054767
- Purity: 100.0 % - Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 2.7
- Temp.:
- 25 °C
- pH:
- 7
- Remarks on result:
- other: 95 % confidence limits 2.50-2.81
- Details on results:
- This result is in reasonable good agreement with the result of a preliminary test log Pow of 2.47, which is obtained by calculation with the computer program CLOGP (version 3.54 - 5190, Pomona College, Medical Chemistry Project, Claremont, USA). This method is based on the summation of molecular increments to the total log P ow of the substance.
- Conclusions:
- The partition coefficient (log Pow) was determined to be 2.7 at 25°C and pH 7.
- Executive summary:
The n-octanol/water partition coefficient (log Pow)was determined according to EU Testing Guideline A.8 (HPLC method based on OECD guideline No. 117) to be 2.7 (95 % confidence limits 2.50 -2.81) at 25 °C, which indicates no lipophilicity. The method is based on the correlation of the reversed phase retention data of the test compound with those of reference compounds with known log Pow values.
Reference
Description of key information
The partition coefficient (log Pow) was determined to be 2.7 at 25°C and pH 7.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.7
- at the temperature of:
- 25 °C
Additional information
There is no classification expected resulting out of the studies concerning the partition coefficient.
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