Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name:
  • IUPAC name: (1R,4aR,4bR,10aR)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,4b,5,6,10,10a-decahydrophenanthrene-1-carboxylic acid; (1R,4aR,4bS,10aR)-1,4a-dimethyl-7-(propan-2-ylidene)-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydrophenanthrene-1-carboxylic acid; (1R,4aS,10aR)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,5,6,9,10,10a-decahydrophenanthrene-1-carboxylic acid; (1R,4aS,10aR)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid
  • Substance names and other identifiers
EC / List no.:
232-475-7
CAS no.:
8050-09-7
Index number:
Molecular formula:
C80H118O8
SMILES:
[H][C@@]12CCC3=C(CCC(=C3)C(C)C)[C@@]1(C)CCC[C@@]2(C)C(O)=O.[H][C@@]12CCC3=C(C=CC(=C3)C(C)C)[C@@]1(C)CCC[C@@]2(C)C(O)=O.[H][C@]12CCC(C=C1CC[C@@]1([H])[C@@](C)(CCC[C@]21C)C(O)=O)=C(C)C.[H][C@]12CCC(=CC1=CC[C@@]1([H])[C@@](C)(CCC[C@]21C)C(O)=O)C(C)C
InChI:
InChI=1/3C20H30O2.C20H28O2/c4*1-13(2)14-6-8-16-15(12-14)7-9-17-19(16,3)10-5-11-20(17,4)18(21)22/h12,16-17H,5-11H2,1-4H3,(H,21,22);12-13,17H,5-11H2,1-4H3,(H,21,22);7,12-13,16-17H,5-6,8-11H2,1-4H3,(H,21,22);6,8,12-13,17H,5,7,9-11H2,1-4H3,(H,21,22)/t16-,17+,19+,20+;17-,19-,20-;16-,17+,19+,20+;17-,19-,20-/s2 AuxInfo=1/1/N:89,90,84,88,86,81,80,78,77,82,85,76,83,79,74,72,73,87,71,75,93,94;68,69,64,66,67,59,58,56,57,62,65,53,61,54,50,49,51,55,48,52,60,63;19,20,14,18,16,11,10,8,7,12,15,6,13,9,4,2,3,17,1,5,23,24;43,44,38,42,40,35,34,32,31,36,39,30,37,33,28,26,27,41,25,29,46,47/E:4*(1,2)(21,22)/rA:94C.oC.oC.oCC.eCCCCCCCCCCCCCCCHHOOC.oCC.oCC.eCCCCCCCCCCCCCCCHOOC.oCCC.oC.oCCCCCCCOCCOCCCCCCHC.oC.oC.oCC.eCCCCCCCCCCCCCCCHHOO/rB:s1;s1;s2;s3;s4;s3;s2;d-6;d-4s7;s8s9;s1;s9;s1;s5;s12s15;s5;s5;s13;s13;s3;s2;d17;s17;;s25;s25;d+26;s27;s28;s27;s26;d-30;s28s31;d-32s33;s25;s33;s25;s29;s36s39;s29;s29;s37;s37;s27;d41;s41;;s48;d+49;s48;s51;s50;d-53;s52;s49;s51;s50s57;s54s56;d55;s54;s48;s55;s48;s52;s52;s62s65;s61;s61;s51;;s71;s71;s72;s73;d-74;s73;s72;s76;s74s77;s78s79;s71;d+79;s71;s75;s82s85;s75;s75;s83;s83;s73;s72;d87;s87;/rC:.9035,-.7116,0;-.6365,-.7116,0;1.6735,.6221,0;-1.4065,.6221,0;3.2135,.6221,0;-2.9465,.6221,0;.9035,1.9557,0;-1.4065,-2.0453,0;-3.7165,-.7116,0;-.6365,1.9557,0;-2.9465,-2.0453,0;1.6735,-2.0453,0;-5.2565,-.7116,0;.1335,-2.0453,0;3.9835,-.7116,0;3.2135,-2.0453,0;2.9461,2.1387,0;4.6606,1.1488,0;-6.0265,-2.0453,0;-6.0265,.6221,0;2.4435,1.9557,0;-.3691,-2.2282,0;1.499,2.6654,0;4.1258,3.1286,0;15.7677,-.8085,0;14.2277,-.8085,0;16.5377,.5252,0;13.4577,.5252,0;18.0776,.5252,0;11.9177,.5252,0;15.7677,1.8588,0;13.4577,-2.1422,0;11.1477,-.8085,0;14.2277,1.8588,0;11.9177,-2.1422,0;16.5377,-2.1422,0;9.6106,-.8085,0;14.9977,-2.1422,0;18.8476,-.8085,0;18.0776,-2.1422,0;17.8102,2.0417,0;19.5219,1.0518,0;8.8406,-2.1422,0;8.8406,.5252,0;17.3076,1.8588,0;16.3632,2.5684,0;18.9899,3.0316,0;-.8875,-9.2452,0;.6525,-9.2452,0;1.4225,-7.9116,0;-1.6575,-7.9116,0;-3.1975,-7.9116,0;2.9625,-7.9116,0;3.7325,-9.2452,0;-2.9301,-6.395,0;1.4225,-10.5789,0;-.8875,-6.5779,0;.6525,-6.5779,0;2.9625,-10.5789,0;-1.483,-5.8683,0;5.2725,-9.2452,0;-1.6575,-10.5789,0;-4.1098,-5.4051,0;-.1175,-10.5789,0;-3.9675,-9.2452,0;-4.6447,-7.3849,0;-3.1975,-10.5789,0;6.0425,-7.9116,0;6.0425,-10.5789,0;-2.4275,-6.5779,0;17.1524,-9.1483,0;15.6124,-9.1483,0;17.9224,-7.8147,0;14.8424,-7.8147,0;19.4623,-7.8147,0;13.3024,-7.8147,0;17.1524,-6.481,0;14.8424,-10.482,0;12.5324,-9.1483,0;15.6124,-6.481,0;13.3024,-10.482,0;17.9224,-10.482,0;10.9924,-9.1483,0;16.3824,-10.482,0;20.2323,-9.1483,0;19.4623,-10.482,0;19.195,-6.2981,0;20.9094,-7.288,0;10.2225,-10.482,0;10.2225,-7.8147,0;18.6924,-6.481,0;15.8798,-10.6649,0;17.7479,-5.7714,0;20.3746,-5.3082,0;
Type of substance:
UVCB
Origin:
Organic
Registered compositions:
72
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Warning! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance may cause an allergic skin reaction.

Breakdown of all 2869 C&L notifications submitted to ECHA

Skin Sens. 1 H317 Harmonised Classification
Resp. Sens. 1 H334
Acute Tox. 4 H332
Eye Irrit. 2 H319
Aquatic Chronic 1 H410
Acute Tox. 4 H312
Skin Irrit. 2 H315
Aquatic Chronic 2 H411
Flam. Sol. 2 H228
Skin Sens. 1A H317
Eye Irrit. 2B H320
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • Ss
Officially recognised in the EU as Skin sensitising ( Harmonised C&L).
  • Ss
There is broad agreement in that a majority of data submitters agree this substance is Skin sensitising (100% of REACH registrations).

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 84 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 100 000 - 1 000 000 tonnes per year.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: lubricants and greases, coating products, biocides (e.g. disinfectants, pest control products), polishes and waxes, adhesives and sealants, fillers, putties, plasters, modelling clay, anti-freeze products, finger paints and inks and toners.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

This substance is used in the following activities or processes at workplace: high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding) and the low energy manipulation of substances bound in materials or articles.

Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)) and indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints).

This substance can be found in complex articles, with no release intended: vehicles and machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines). This substance can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones), paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper) and wood (e.g. floors, furniture, toys).

This substance is used in the following products: coating products, welding & soldering products, adhesives and sealants, polymers, lubricants and greases, fuels and laboratory chemicals.

This substance is used in the following areas: printing and recorded media reproduction. This substance is used for the manufacture of: food products, machinery and vehicles and electrical, electronic and optical equipment.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure, roller or brushing applications, non-industrial spraying, treatment of articles by dipping and pouring, closed batch processing in synthesis or formulation and batch processing in synthesis or formulation with opportunity for exposure.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

This substance is used in the following products: coating products, inks and toners, polymers, perfumes and fragrances, adhesives and sealants and laboratory chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, transfer of substance into small containers, production of mixtures or articles by tabletting, compression, extrusion or pelletisation, laboratory work, closed batch processing in synthesis or formulation and closed processes with no likelihood of exposure.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and formulation in materials.

This substance is used in the following products: coating products, welding & soldering products, polymers, adhesives and sealants, laboratory chemicals, fuels and paper chemicals and dyes.

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals and pulp, paper and paper products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, closed processes with no likelihood of exposure, batch processing in synthesis or formulation with opportunity for exposure, laboratory work and treatment of articles by dipping and pouring.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), of substances in closed systems with minimal release, as processing aid, as processing aid and for thermoplastic manufacture.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; avoid breathing the dust, fume, gas, mist, vapours or spray.

Response statements

In case of incident: Wash contaminated clothing before reuse. If skin irritation or a rash occurs: get medical advice/attention. If on skin: wash with soap and water.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • A V Pound & Co. Ltd, Goolds Hill House Old Cork Road Ireland Mallow Co. Cork Ireland
  • AAKO BV, Arnhemseweg 87 3832 GK Leusden Netherlands
  • Alfonso Criado Martín, Camino de los Molinos, 33 40293 Zarzuela del Pinar Segovia Spain
  • B-Lands Consulting (811234-5), World Trade Center, 5 Place Robert Schuman - BP 1510 38025 Grenoble France France
  • Barcelona Technical Consultancy SLU (acting as OR for POLYTRADE), Osona 2 08820 El Prat de Llobregat Barcelona [Catalonia] Spain
  • Berner Ltd, Hitsaajankatu 24 00810 Helsinki Finland
  • Biolandes, Route de Belis 40420 Le Sen Landes France
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Chemservice S.A. (4T8L), 5, an de Laengten 6776 Grevenmacher Luxembourg
  • Clariant Plastics & Coatings (Deutschland) GmbH, Brüningstrasse 50 65929 Frankfurt am Main Germany
  • Diamantino Malho & C.ª Lda., Rua da Cerca, 18 3100-081 Albergaria dos Doze Pombal Portugal
  • DRT OR FOR PINOVA, 30 rue Gambetta BP 206 40105 Dax France
  • Eastman Chemical Middelburg B.V., Herculesweg 35 4338 PL Middelburg Netherlands
  • EIGENMANN & VERONELLI IBÉRICA, S.L., Polígono Industrial La Pedrosa C/ Miguel Hernández, 42 - 44 Nave A 08908 L’Hospitalet de Llobregat - Barcelona Spain
  • EUROCHEMICALS PINEROSINS PORTUGAL S.A., Avenida de São Romão 4935-546 NEIVA Viana do Castelo Portugal
  • Forchem Oyj, P.O. Box 16 26101 Rauma Finland
  • G.C. RUTTEMAN & Co. B.V., P.O. Box 30028 3001 DA Rotterdam Netherlands
  • GIANNAKOS DIM. KONSTANTINOS, 2nd KM PSACHNON - POLITIKON 34400 PSACHNA, EVIA Greece
  • Globe Chemicals GmbH, Spohrstrasse 2 22083 Hamburg Germany
  • Grupo DRV Phytolab S.L., C/ Oro, 10 -Oficinas Centrales- (P. I. Sur) C/ Acero, 26 -Fábrica- (P. I. Sur) 28770 Colmenar Viejo España Spain
  • GUM CHEMICAL SOLUTIONS, S.A., Zona Industrial de Cantanhede, lote 135 3060-197 Cantanhede Portugal
  • H. Reynaud & Fils (Deutschland) GmbH, Rahlstedter Bahnhofstrasse 10 22143 Hamburg Hamburg Germany
  • HH Compliance Ltd., Rubicon Building, CIT Campus Bishopstown none Cork Ireland
  • Iberian Resins, Avenida da Igreja, nº14, rch 6300 - 399 Guarda Portugal
  • INDUSTRIAL RESINERA VALCAN S.A, CTRA DE ALCAZAR S/N 16003 CUENCA CASTILLA LA MANCHA Spain
  • Intechnica Consult GmbH, Ostendstrasse 181 90482 Nuernberg Germany
  • International Chemicals Management, Bennekomstraat 10 2573RE Den Haag Zuid Holand Netherlands
  • Intertek Deutschland GmbH 6, Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • ITS Testing Services (UK) Ltd 6SC, Caleb Brett House 734 London Road RM20 3NL West Thurock, Grays Essex United Kingdom
  • JSC "Margunas", Ringuvos 53 LT-45245 Kaunas Lithuania
  • Kemira Chemie GesmbH, Hafenstrasse 77 AT-3500 KREMS Austria
  • Kemira Oyj, Energiakatu 4 P.O.Box 330 FI-00101 HELSINKI Finland
  • Knoell NL_OR_051, Agro Business Park 75 6708 PV Wageningen Netherlands
  • Kraton Chemical AB, Massvagen15 P.O.BOX 66 SE-82022 Sandarne Sweden
  • Kraton Chemical AB OR1, Massvagen 15 P.O. Box 66 SE-820 22 Sandarne Sweden
  • Kraton Chemical B.V., Transistorstraat 16 1322 CE Almere Netherlands
  • Kraton Chemical OY, Nuottasaarentie 17 FIN-90400 OULU Finland
  • Lawter BVBA, Haven 1520 Ketenislaan 1 B-9130 Kallo East Flanders Belgium
  • Lawter BVBA OR, Haven 1520 Ketenislaan 1C B-9130 Kallo Belgium
  • LES DERIVES RESINIQUES ET TERPENIQUES, 30 rue Gambetta B.P. 206 40105 Dax Cedex France
  • Lonza Cologne GmbH, Nattermannallee 1 50829 Cologne Germany
  • LURESA RESINAS S.L., Paseo de la Castellana 153, 8ºB 28046 MADRID Spain
  • LURESA RESINAS SL, PASEO DE LA CASTELLANA 153, 8ºB 28046 MADRID Spain
  • Luxcontrol S.A. (OR4), 1, Avenue des Terres Rouges 4004 Esch-sur-Alzette Luxembourg
  • Manuel Inácio Pimpão & Filhos , Rua da Fábrica n12 Porto Carro 2405-030 Maceira / Leiria Portugal
  • Manufacture Française des Pneumatiques Michelin (OR US), Place des Carmes Déchaux 63040 Clemront Ferrand France
  • MEGARA RESINS - ANASTASSIOS FANIS S.A., 38th km new national road athens - corinth 19100 Megara Greece
  • MFPM Only Representative pour Michelin India Tamilnadu Tyres Private Limited, Place des Carmes Déchaux Site de Ladoux - Batiment G22 63040 Clermont-Ferrand France
  • MHM Holding GmbH, Feldkirchener Straße 15 D-85551 Kirchheim Germany
  • MICHAIL MICHAIL RESIN PRODUCTS, Pefki 34200 Istiaia Evia Greece
  • Michelin Reifenwerke AG & Co. Kommanditgesellschaft auf Aktien, Michelinstrasse 4 76185 Karlsruhe Germany
  • NSW TOSCANA TRADING SRL, Via Queirolo, 18 51016 Montecatini Terme Pistoia Italy
  • NYMCO S.p.A., V. C. Magni 1 21049 Tradate Varese Italy
  • OPEN AGE srl, Via Campania, 14 26855 Lodi Vecchio (LO) Italy
  • Performance Specialty Products Ibérica, S.L.U., Valle de Tamón - Nubledo 33469 Tamón - Carreño Asturias Spain
  • Petrofer GmbH, Hegenheimer Strasse 18 79576 Weil am Rhein Germany
  • Pino Pine - Produtos Quimicos SA, Rua da Carreira Branca, nº 26 Zona Industrial da Taboeira, Esgueira 3800-373 Aveiro Aveiro Portugal
  • Prorresina, Casal de Cima 3330-128 Alvares Portugal
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland
  • Resinas y Colofonias Modificadas S.A., Paraje La Carrasca s/n 02400 Hellín Albacete Spain
  • Respol, Resinas, SA, Estrada das Moitas Altas Pinheiros 2415-746 Leiria Leiria Portugal
  • Robert Kraemer GmbH & Co. KG, Zum Roten Hahn 9 26180 Rastede Germany
  • SCAS Europe S.A./N.V., Leonardo Da Vincilaan 19 B-1831 Diegem Belgium
  • SI Group-Béthune S.A.S., 1111 Avenue George Washington Boite Postale 237 62404 Cedex Béthune France
  • Simpsons UK Ltd, Unit 1,Beacon Business Park, Severnbridge Industrial Estate Caldicot NP26 5PX Caldicot Gwent,South Wales,U.K. United Kingdom
  • Sociedad de resinas naturales S.L, Polígono de villa y tierra, nave 26, 40200 Cuéllar (Segovia) Castilla y León Spain
  • Sun Chemical B.V., Leeuwenveldseweg 3-t 1382 LV Weesp Netherlands
  • SunPine AB, P.O. Box 76 SE-941 22 Piteå Norrbotten Sweden
  • SUNRY IMPORT & EXPORT GMBH, frankenstrasse 3 20097 Hamburg Germany
  • Sustainability Support Services (Europe) AB, Markaskälsvägen 6 22647 Lund Sweden
  • TECNICAS AVANZADAS DE DESTILACION DE RESINAS NATURALES S.L, Ctra Cuellar- Arevalo km 25 40470 Navas de Oro Spain
  • TER HELL & Co. GmbH, Boersenbruecke 2 20457 Hamburg Germany
  • Toyo Ink Europe Specialty Chemicals, Boulevard Dambourney 76350 OISSEL France
  • Toyo ink europe specialty chemicals, Boulevard Dambourney BP 4 76350 Oissel France
  • United Resins - Produção de Resinas SA, Parque Industrial e Empresarial da Figueira da Foz Praça das Oliveiras - LOTE 126 3090-380 Figueira da Foz Portugal
  • VIEIRIFABRIL, LDA, Estrada Nacional 109 Vieirinhos 3105-069 CARRIÇO Pombal Leiria Portugal
  • Willers, Engel & Co. (GmBH & Co.), Grimm 8 20457 Hamburg Germany
  • Yordas GmbH, Äußere Nürnberger Str. 6 91301 Forchheim Germany
  • BASF Colors & Effects GmbH, An der Rheinschanze 1 67059 Ludwigshafen Germany
  • Häffner International GmbH, Steinhoeft 5-7 Haus am Hafen 20459 Hamburg Hamburg Germany
  • Manuel Benzinho da Costa & Filhos Lda, Cartaria 3100-082 Albergaria dos Doze Pombal Portugal
  • Nouryon Pulp and Performance Chemicals AB, Färjevägen 1 SE-445 80 Bohus Sweden
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 FI-02600 Espoo Finland
  • SRN Ibérica - Import & Export, Lda., Rua Cova da Moura nº 2, 2ºDto 1350-077 Lisboa Portugal Portugal

Substance names and other identifiers

Rosin
EC Inventory, REACH pre-registration
rosin; colophony
A complex combination derived from wood, especially pine wood. Composed primarily of resin acids and modified resin acids such as dimers and decarboxylated resin acids. Includes rosin stabilized by catalytic disproportionation.
C&L Inventory
colofonia (es)
C&L Inventory
colofónia (pt)
C&L Inventory
colophane (fr)
C&L Inventory
fenyőgyanta; kolofónium (hu)
C&L Inventory
kalafonia (pl)
C&L Inventory
kalafuna (cs)
C&L Inventory
kanifolija (lt)
C&L Inventory
Kolofoni (fi)
C&L Inventory
kolofonija (sl)
C&L Inventory
kolofonium (no)
C&L Inventory
kolofónia (sk)
C&L Inventory
Kolophonium (da)
C&L Inventory
naturharts (sv)
C&L Inventory
pvnhars (nl)
C&L Inventory
Rosiin; Kolofoon (et)
C&L Inventory
rosin; colofoniu (ro)
C&L Inventory
rosin;kolofonij (hr)
C&L Inventory
rosina, colofonia (it)
C&L Inventory
rozīns, kolofonijs (lv)
C&L Inventory
terpentinoliefri harpiks (da)
C&L Inventory
Κολοφώνιο (el)
C&L Inventory
дървесна смола; колофон (bg)
C&L Inventory
(1R,4aR,4bR,10aR)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,4b,5,6,10,10a-decahydrophenanthrene-1-carboxylic acid; (1R,4aR,4bS,10aR)-1,4a-dimethyl-7-(propan-2-ylidene)-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydrophenanthrene-1-carboxylic acid; (1R,4aS,10aR)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,5,6,9,10,10a-decahydrophenanthrene-1-carboxylic acid; (1R,4aS,10aR)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acid
C&L Inventory, Registration dossier, Other
(1R,4aR,4bR,10aR)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,4b,5,6,10,10a-decahydrophenanthrene-1-carboxylic acid; (1R,4aR,4bS,10aR)-1,4a-dimethyl-7-(propan-2-ylidene)-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydrophenanthrene-1-carboxylic acid; (1R,4aS,10aR)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,5,6,9,10,10a-decahydrophenanthrene-1-carboxylic acid; (1R,4aS,10aR)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,9,10,10a-octahydrophenanthrene-1-carboxylic acidSynonyms
Registration dossier
(1R,4aR,4bR,10aR)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,4b,5,6,10,10a-decahydrophenanthrene-1-carboxylic acid;(1R,4aR,4bS,10aR)-1,4a-dimethyl-7-(propan-2-ylidene)-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydrophenanthrene-1-carboxylicacid; (1R,4aS,10aR)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,5,6,9,10,10a-decahydrophenanthrene-1-carboxylic acid;(1R,4aS,10aR)-1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,9,10,10aoctahydrophenanthrene-1-carboxylic acid
Registration dossier
(1R,4aR,4bR,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,4b,5,6,10,10a-octahydrophenanthrene-1-carboxylic acid
C&L Inventory, Registration dossier
(2R,3S,4S,5R,6R) - 2-(hydroxymethyl)-6-[(E)-3-phenylprop-2-epoxy]
C&L Inventory
(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[(E)-3-phenylprop-2-enoxy]oxane-3,4,5-triol
C&L Inventory
(5β,9β)-Abieta-7,13-dien-19-oic acid
C&L Inventory
2,4,6-tritert-butylphenol
C&L Inventory
2-(hydroxymethyl)-6-(3-phenylprop-2-enoxy)oxane-3,4,5-triol
C&L Inventory
? rosin; colophony
C&L Inventory
abieta-7,13-dien-18-oic acid
Registration dossier
abietic acid
C&L Inventory
abietic anhydride
C&L Inventory
Chinese Gum Rosin
C&L Inventory
Colophonium
C&L Inventory
Colophony
C&L Inventory
Diprosin A 100
C&L Inventory
Disproportionated Rosin
Registration dossier
Ester Resin
Registration dossier
Gum Rosin
C&L Inventory, Registration dossier
Not available
C&L Inventory
pryskyřice přírodní
C&L Inventory
Respin, natural resin.
Registration dossier
ROSIN / Pinus Pinaster, Pinaceae, distillation
C&L Inventory
Rosin, colophony
C&L Inventory
rosin, gum
C&L Inventory
Rosin-
C&L Inventory
Rosin.(1) Source: Family: Pinaceae; Genus: Pinus.(2)Process: Rosin is a UVCB sub-type 3, where the source is biological and the process is refinement. The common refinement step is distillation.
Registration dossier
rosin;
C&L Inventory
rosin; colophony [1]rosin; colophony [2]rosin; colophony [3]
C&L Inventory
rosin;colophony
C&L Inventory
Brazilian Gum Rosin
Registration dossier
Breutex
Registration dossier
Breutex S
Registration dossier
COL 1440
Registration dossier
COL 15
Registration dossier
COL 240
Registration dossier
COL 90
Registration dossier
Flytac 101
Registration dossier
Foral AX
Registration dossier
GUM ROSIN WW
Registration dossier
Gum Rosin, colophony
Registration dossier
Indonesian Gum Rosin
Registration dossier
Indonesian Gum Rosin X/ WW/ WG
Registration dossier
Staybelite
Registration dossier
Staybelite A
Registration dossier
Vinsol Flake
Registration dossier
Vinsol Flaked
Registration dossier
Vinsol Pulverized
Registration dossier
XTOL 777 Formulated Tall Oil
Registration dossier
YT 101
Registration dossier
118817-23-5
Deleted CAS number
Other
1481684-92-7
Deleted CAS number
Other
37271-91-3
Deleted CAS number
Other
39390-87-9
Deleted CAS number
Other
650-015-00-7
Index number
C&L Inventory
68153-42-4
Deleted CAS number
Other
8050-09-7
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other
8050-10-0
Deleted CAS number
Other
8050-14-4
Deleted CAS number
Other
8052-47-9
Deleted CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 1 study submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [1]
C Form
Not specified (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 1 study submitted
  • 1 study processed
R Melting / freezing point
66.5 - 93.4 °C @ 101.325 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Boiling point

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Density

Study results
  • 1 study submitted
  • 1 study processed
R Relative density
1 034 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Vapour pressure

Study results
  • 1 study submitted
  • 1 study processed
R Vapour pressure
10.8 kPa @ 200 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Partition coefficient

Study results
  • 4 studies submitted
  • 1 study processed
R Log Pow
1.9 - 7.7 @ pH 2 - 7 [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Water solubility

Study results
  • 5 studies submitted
  • 1 study processed
R Water solubility (mass/vol.)
900 µg/L @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 3 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Auto flammability

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flammability

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Explosiveness

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 28 studies submitted
  • 7 studies processed
C Interpretation of results
Readily biodegradable (100%) [7]

Type of Study provided
Studies with data
Key study 5 4
Supporting study 10 5
Weight of evidence
Other 2 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 21 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2 10 9
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 17 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 8 9
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 1.6 µg/L (1)
Intermittent releases (freshwater) 16 µg/L (1)
Marine water 160 ng/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 1 g/L (1)
Sediment (freshwater) 7 µg/kg sediment dw (1)
Sediment (marine water) 700 ng/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 450 ng/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 20 studies submitted
  • 8 studies processed
P/RResults
LC50 (4 days) 1.7 - 5.4 mg/L [4]
LC0 (4 days) 2.5 mg/L [2]
LC100 (4 days) 10 mg/L [2]
NOEC (4 days) 625 µg/L [2]
LL50 (4 days) 10 mg/L [2]

Type of Study provided
Studies with data
Key study 5 3
Supporting study 4 2
Weight of evidence
Other 3 3
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 20 studies submitted
  • 11 studies processed
P/RResults
LC50 (48 h) 1.6 mg/L [2]
NOEC (48 h) 625 µg/L [2]
EL50 (48 h) 36 - 2 000 mg/L [9]
NOELR (48 h) 10 - 750 mg/L [7]

Type of Study provided
Studies with data
Key study 6 5
Supporting study 2 1
Weight of evidence
Other 3 3
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to aquatic algae and cyanobacteria

Study results
  • 14 studies submitted
  • 5 studies processed
P/RResults
EC50 (72 h) 16.6 - 39.6 mg/L [4]
NOEC (72 h) 6.25 mg/L [4]
EL50 (72 h) 100 - 1 000 mg/L [4]
NOELR (72 h) 100 - 1 000 mg/L [4]

Type of Study provided
Studies with data
Key study 3 2
Supporting study 2 1
Weight of evidence
Other 3 3
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (3 h) 10 g/L [1]
EC10 (3 h) 10 g/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
Local Effects
Long-term: - -
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2.131 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
Local Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.065 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.065 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential

Acute toxicity

Study results
oral
  • 13 studies submitted
  • 9 studies processed
P/RResults
LD50 1 000 - 5 000 mg/kg bw (rat) [5]
approx. LD50 2 000 mg/kg bw (rat) [1]
M/CInterpretations of results
Other [9]

Type of Study provided
oral
Studies with data
Key study 5 4
Supporting study 2 2
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
dermal
  • 3 studies submitted
  • 3 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [3]
M/CInterpretations of results
Other [3]

dermal
Studies with data
Key study 2 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
No adverse effect observed LD50 2 000 mg/kg bw
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 4 3
Supporting study 1 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 5 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 32 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 6 5
Supporting study 14 5
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 29 studies submitted
  • 2 studies processed
P/RResults
NOAEL (rat): 3 000 - 5 000 ppm [2]

Type of Study provided
Study data: oral
Studies with data
Key study 3 2
Supporting study
Weight of evidence 13 10
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: inhalation
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Study data: dermal
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Genetic toxicity

Study results
Study data: in vitro
  • 17 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 9 7 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to reproduction

Study results
Study data: reproduction
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 6 3
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Study data: developmental
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on developmental toxicity
Oral route:
Adverse effect observed NOAEL 387.2 mg/kg bw/day (subacute, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant