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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 418-940-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EEC-Directive 92/69 B.1
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test animals
- Species:
- other: rat / Wistar Crl:(WI)BR
Administration / exposure
- Vehicle:
- other: 1% Aqueous carboxymethyl cellulose
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 832 mg/kg bw
- Remarks on result:
- other: Slope of the mortality curve: 24.6
- Mortality:
- Male: 400 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 900 mg/kg bw; Number of animals: 5; Number of deaths: 4
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 5
Female: 400 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 900 mg/kg bw; Number of animals: 5; Number of deaths: 4
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 5 - Clinical signs:
- Signs of toxicity related to dose levels:
The deaths occurred between approx. 30 minutes and 24 hours
after dosing.
Clinical signs:
400 mg/kg: Lethargy, hunched posture, uncoordinated
movements, pale appearance, salivation, watery discharge
from the eyes.
900 mg/kg: Lethargy, tremors, ventro-lateral recumbency,
hunched posture, uncoordinated movements, pale appearance,
watery discharge from the eyes, dark coloured eyes.
2000 mg/kg: Lethargy, tremors, tonic spasms.
Symptoms had disappeared in the surviving animals between 2
hours and 6 days after dosing. - Gross pathology:
- Effects on organs:
Body weight: no findings
Macroscopic:
Haemorrhages in the glandular stomach observed among animals
that died during the study. Haemorrhages in the thymus were
observed in one animals that died during the study.
No further findings.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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