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Diss Factsheets
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EC number: 939-248-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2013
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 417 (Toxicokinetics)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Certificate nr 2011/40 on July 19th 2011
Test material
- Reference substance name:
- PROCESS OIL
- IUPAC Name:
- PROCESS OIL
- Test material form:
- gas under pressure: refrigerated liquefied gas
Constituent 1
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- Oral
- Type:
- absorption
- Results:
- Dermal
- Type:
- absorption
- Results:
- Inhalation
- Type:
- distribution
- Results:
- Bioaccumulation
- Type:
- metabolism
- Type:
- excretion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Oral:
In the acute oral toxicity study in rats, noclear systemic effects were found up to the highest dose of 2000 mg/kg. The only potential effect of OIL T279 was an equivocal slightly reduced mean weight gain (when compared with historical control data) at 2000 mg/kg, which was probably related to stress.
Dermal:
The assumed high molecular weight of the constituents of OIL T279 would be expected to preclude passage across the skin.
Inhalation:
No inhalative toxicity are available for OIL T279. Based on the physical state, vapour pressure, high molecular weight and boiling point (non volatile liquid), fugacity is expected to be very low. Based on these data, systemic exposure by this route of exposure could be expected to be negligible. - Details on distribution in tissues:
- Measured levels of analytes in body fluids (blood, plasma), organs or excreta (urine, faeces) are not available for OIL T279. In any case, it would not be feasible to generate such data for each of the components of OIL T279.
Distribution may be assessed from systemic effects observed in toxicology studies. No conclusions can be drawn on distribution, in view of the lack of any proof of absorption in the available animal studies.
Bioaccumulation:
The lack of any worsening toxicity with continued treatment in the repeated dose studies does not point to any indications of bioaccumulation. This does not,however, preclude the bioaccumulation of non-toxic components of OIL T279 with no physiological conséquences.
- Details on excretion:
- Experimental excretion data are not available for OIL T279. Some hints about the excretion pattern may be derived from the results of toxicity studies. No noteworthy coloration (urine, faeces), odour or lesions of gastro-intestinal or urinary tracts were noted in any oral or dermal toxicity study. Therefore, no conclusions could be drawn on the route of excretion.
Metabolite characterisation studies
- Metabolites identified:
- not measured
Any other information on results incl. tables
Metabolism:
. The addition of S9 mix did not have any noticeable effect on the solubilitu of the test item.
. No genotoxicity of OIL T279 was found, with or without S9 mix.
. The addition of S9 mix generall led to decreased cytotoxicity. Therefore, there is a strong indication that liver enzymes are able to metabolize OIL T279 to less cytotoxic metabolites. However, the biological pertinence of this finding very limited in view of the lack of demonstrated systemic exposure following oral or dermal administration.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
No indication of possible bioaccumulation of toxicologically relevant components in the performed toxicity studies.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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