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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_physical-and-chemical-properties.png)
Boiling point
Administrative data
- Endpoint:
- boiling point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 AUG 2022 TO 05 OCT 2022
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30 AUG 2022 TO 05 OCT 2022
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Version / remarks:
- November 2019
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Version / remarks:
- July 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7200 (Melting Point / Melting Range)
- Version / remarks:
- March 1998
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- lot/batch number of test material: 22BN0551
- Expiry date: 28 April 2023 (retest date)
- Physical Description: Off-white powder
- Purity: 98.3%
- Purity correction factor: no correction factor required
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Final preparation of a solid: not applicable, the solid test item was transferred directly into the DSC cell - Key result
- Melting / freezing pt.:
- 133.4 °C
- Atm. press.:
- 1 atm
- Decomposition:
- yes
- Decomp. temp.:
- 225 °C
- Conclusions:
- The melting temperature of JNJ-63632283-AAA (T003665) was tested by DSC.
The melting temperature of the test material was 133.4°C.
Reaction and/or decomposition of the test material was observed during DSC experiment starting at 225°C.
Preliminary test
From the TGA curve it could be derived that starting at at 225°C, the weight of the sample decreased significantly. At 289°C, the sample weight had decreased by 25%. After the experiment, a dark brown molten residue remained in the sample container (original colour: off-white). The change of the colour indicated reaction and/or decomposition of the test material.
Many study
From the DSC curce obtained with Experiment 1, an endothermic effect was observed between 125°C and 150°C. The extrapolated onset temperature of the effect was 133.453°C. The endothermic effect was most likely obtained due to melting of the test material. Starting from 225°C, an exothermic effect was observed. It was most likely due to reaction and/or decomposition of the test material. After the experiment, a dark brown molten residue remained in the sample container (original colour: off-white).
In order to investigate the endothermic effect, Experiment 2 was stopped directly after the melting effect. During Experiment 2 a technical error in the equipment occurred. Therefore, the results of Experiment 2 were discarded.
Experiment 3 was performed to investigate the endothermic effect found in Experiment 1 and was directly stopped after the melting effect. From the DSC curve obtained, the extrapolated onset temperature was 133.426°C. After the experiment, a molten off-white residue remained in the sample container (original colour: off-white). It demonstrated that melting was the reason for the endothermic effect.
The melting temperature was determined as the mean melting temperature of Experiment 1 (133.453°C) and Experiment 3 (133.426°C).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 022
- Report date:
- 2022
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.2 (Boiling Temperature)
- Version / remarks:
- November 2019
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 103 (Boiling Point)
- Version / remarks:
- July 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7220 (Boiling Point / Boiling Range)
- Version / remarks:
- August 1996
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
Test material
- Reference substance name:
- 1-amino-N-[6-cyano-5-(trifluoromethyl)-3- pyridyl]cyclobutanecarboxamide
- Cas Number:
- 1950587-17-3
- Molecular formula:
- C12H11F3N4O
- IUPAC Name:
- 1-amino-N-[6-cyano-5-(trifluoromethyl)-3- pyridyl]cyclobutanecarboxamide
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material: JNJ-63632283-AAA (T003665)
- Physical state: solid (powder)
- Appearance: white powder
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- lot/batch number of test material: 22BN0551
- Expiry date: 28 April 2023 (retest date)
- Physical Description: Off-white powder
- Purity: 98.3%
- Purity correction factor: no correction factor required
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Final preparation of a solid: not applicable, the solid test item was transferred directly into the DSC cell
Results and discussion
Boiling point
- Key result
- Atm. press.:
- 1 atm
- Decomposition:
- yes
- Decomp. temp.:
- 225 °C
- Remarks on result:
- other: Boiling of the test material was not observed below the temperature at which reaction and/or decomposition started. Based on this, the test material has no boiling temperature.
Any other information on results incl. tables
Preliminary test
From the TGA curve it could be derived that starting at at 225°C, the weight of the sample decreased significantly. At 289°C, the sample weight had decreased by 25%. After the experiment, a dark brown molten residue remained in the sample container (original colour: off-white). The change of the colour indicated reaction and/or decomposition of the test material.
Many study
From the DSC curce obtained with Experiment 1, an endothermic effect was observed between 125°C and 150°C. The extrapolated onset temperature of the effect was 133.453°C. The endothermic effect was most likely obtained due to melting of the test material. Starting from 225°C, an exothermic effect was observed. It was most likely due to reaction and/or decomposition of the test material. After the experiment, a dark brown molten residue remained in the sample container (original colour: off-white).
In order to investigate the endothermic effect, Experiment 2 was stopped directly after the melting effect. During Experiment 2 a technical error in the equipment occurred. Therefore, the results of Experiment 2 were discarded.
Experiment 3 was performed to investigate the endothermic effect found in Experiment 1 and was directly stopped after the melting effect. From the DSC curve obtained, the extrapolated onset temperature was 133.426°C. After the experiment, a molten off-white residue remained in the sample container (original colour: off-white). It demonstrated that melting was the reason for the endothermic effect.
Boiling of the test material was not observed below the temperature at which reaction and/or decomposition started. Based on this, the test material has no boiling temperature.
Applicant's summary and conclusion
- Conclusions:
- The boiling temperature of JNJ-63632283-AAA (T003665) were tested by DSC.
Reaction and/or decomposition of the test material was observed during DSC experiment starting at 225°C. Boiling of the test material was not observed below the temperature at which reaction and/or decomposition started. Based on this, the test material has no boiling temperature.
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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