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EC number: 605-420-3 | CAS number: 165950-84-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 Oct 2017 - 01 Nov 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 2004
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- (6S)-6-(propylamino)-5,6,7,8-tetrahydronaphthalen-1-ol hydrobromide
- EC Number:
- 605-420-3
- Cas Number:
- 165950-84-5
- Molecular formula:
- C13H20BrNO
- IUPAC Name:
- (6S)-6-(propylamino)-5,6,7,8-tetrahydronaphthalen-1-ol hydrobromide
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Appearance: White powder
- Storage condition of test material: At room temperature
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: Control and all test concentrations
- Sampling method: 1.8 mL taken from the approximate centre of the test vessels, at t=0 h and t=48 h.
- At the end of the exposure period, the replicates were pooled at each concentration before sampling.
- Sample storage conditions before analysis: Samples were stored in a freezer (≤-15°C) until analysis at the analytical laboratory of the Test Facility.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: Direct addition to the medium. Test solutions were prepared at the highest concentration of 100 mg/L. No other treatment than vigorous shaking was needed to completely dissolve the test item in medium. Lower test concentrations were prepared by subsequent dilutions of the highest concentration in test medium. All test solutions were clear and colorless at the end of the preparation procedure.
- Controls: Test medium without test item or other additives.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain/clone: Straus 1820
- Source: In-house laboratory culture with a known history
- Age of parental stock: >2 weeks old
- Age at test initiation: <24 hours
- Validity of batch: Daphnids originated from a healthy stock, 2nd to 5th brood, showing no signs of stress such as mortality >20%, presence of males, ephippia or discoloured animals and there was no delay in the production of the first brood.
CULTIVATION
- Start of each batch: With newborn daphnids, i.e. less than 3 days old, by placing about 250 of them into 5 litres of M7 medium in an all-glass culture vessel.
- Maximum age of the cultures: 4 weeks
- Renewal of the cultures: After 7 days of cultivation half of the medium twice a week.
- Temperature of medium: 18-22°C
- Feeding: Daily, a suspension of fresh water algae.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 180 mg/L (as CaCO3)
- Test temperature:
- 19-20°C
- pH:
- 7.8-8.1
- Dissolved oxygen:
- 8.9-9.0 mg/L
- Nominal and measured concentrations:
- Nominal: 0.10, 1.0, 10 and 100 mg/L
Measured: Only the limit concentration was analyzed: 104 mg/L at t=0 h, 102 mg/L at t=48 h. The measured concentrations were 102-104% of nominal concentrations throughout the test. Therefore, effects parameters were based on nominal concentrations. See Table 1 in 'Any other information on results' for details on the measured concentrations throughout the test. - Details on test conditions:
- The test was performed as Combined Limit/Range-Finding test.
TEST SYSTEM
- Test vessel: 60 mL all-glass
- Aeration: no
- Feeding: no
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 2 for 0.10 and 1.0 mg/L; 4 for 100 mg/L
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Adjusted ISO medium, prepared with tap water purified by Reverse Osmosis
- Culture medium different from test medium: yes, M7 medium
- Intervals of water quality measurement: Dissolved oxygen and pH: at beginning and end of the test, for the highest concentration and the control. Temperature: continuously in a temperature control vessel, beginning at the start of the test.
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 h photoperiod daily
EFFECT PARAMETERS MEASURED
- Immobility (including mortality) at 24 hours and at 48 hours. - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate (performed Sep 2017)
Results and discussion
Effect concentrations
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Behavioural abnormalities: none observed in the Control group.
- Mortality of control: none
- All water quality parameters remained within the requirements as laid down in the study plan throughout the test. - Results with reference substance (positive control):
- - Results with reference substance valid?
yes
- The 24h-EC50 was 0.59 mg/L with a 95% confidence interval between 0.52 and 0.68 mg/L.
- The 48h-EC50 was 0.41 mg/L with a 95% confidence interval between 0.34 and 0.46 mg/L.
- The actual responses in this reference test with K2Cr2O7 are within the ranges of the expected responses at the different concentrations, i.e. the 48h-EC50 was between 0.3 and 1.0 mg/L. Hence, the sensitivity of this batch of D. magna was in agreement with the historical data collected at the Test Facility.
Any other information on results incl. tables
Table 1: Test Samples
Time of sampling |
Concentration |
Relative to nominal |
Relative to initial |
|
Nominal |
Analyzed |
|||
0 |
0 |
n.d. |
n.a. |
|
|
100 |
104 |
104 |
|
48 |
0 |
n.d. |
n.a. |
n.a. |
|
100 |
102 |
102 |
99 |
n.d. Not detected.
n.a. Not applicable.
Table 2: Number of Introduced Daphnids and Incidence of Immobility
Time (h) |
Replicate |
Nominal concentration (mg/L) |
|||
Control |
0.10 |
1.0 |
100 |
||
0 |
A |
5 |
5 |
5 |
5 |
B |
5 |
5 |
5 |
5 |
|
C |
5 |
|
|
5 |
|
D |
5 |
|
|
5 |
|
Total introduced |
20 |
10 |
10 |
20 |
|
24 |
A |
0 |
0 |
0 |
0 |
B |
0 |
0 |
0 |
0 |
|
C |
0 |
|
|
1 |
|
D |
0 |
|
|
1 |
|
Total immobilised |
0 |
0 |
0 |
2 |
|
Effect % |
0 |
0 |
0 |
10 |
|
|
|
|
|
||
48 |
A |
0 |
0 |
0 |
0 |
B |
0 |
0 |
0 |
1 |
|
C |
0 |
|
|
2 |
|
D |
0 |
|
|
1 |
|
Total immobilised |
0 |
0 |
0 |
4 |
|
Effect % |
0 |
0 |
0 |
20 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- For details on validity criteria, please refer to section 'Overall remarks'
- Conclusions:
- The 48h-EC50 for Daphnia magna exposed to the test item exceeded a nominal concentration of 100 mg/L.
- Executive summary:
In a 48 h acute toxicity test conducted according to OECD guideline 202, Daphnia magna were exposed to the test item at nominal concentrations of 0.1, 1.0 and 10 mg/L (duplicate, 5 daphnids per replicate) and 100 mg/L and an untreated control (both quadruplicate, 5 daphnids per replicate). Measured concentrations were at 102 -104% relative to nominal throughout the test. Therefore, effect parameters were based on nominal concentrations. No immobility was observed in the control and the two lowest test concentrations throughout the test, while 20% effect was observed at the highest concentration after 48 h of exposure. The 48h-EC50 for Daphnia magna exposed to the test item exceeded a nominal concentration of 100 mg/L. The study is considered to be reliable without restrictions.
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