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Diss Factsheets
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EC number: 947-990-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- other: expert statement
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a (Q)SAR model, with limited documentation / justification, but validity of model and reliability of prediction considered adequate based on a generally acknowledged source
- Justification for type of information:
- The logPow values referred to in this expert statement were predicted using EPI Suite™ v4.11, KOWWIN v1.68 (US EPA) and XLOGP3-AA method (Kim et. al., 2015).
- Reason / purpose for cross-reference:
- reference to other study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- other: EPI Suite™ v4.11, KOWWIN v1.68
- Qualifier:
- according to guideline
- Guideline:
- other: XLOGP3-AA method
- Principles of method if other than guideline:
- The partition coefficient was assessed based on available data on experimental/calculated logPow for its constituents.
- Type of method:
- other: expert statement based on experimental/calculated data
- Type:
- log Pow
- Remarks on result:
- other: see field details on results
- Details on results:
- Bos taurus, milk, fermented, spray-dried (EC 917-734-0) is a multi-constituent substance consisting mainly of lactose (40 %), different proteins (34 %), water (8 %), raw ash (8 %) and lactic acid (3 %) (see section 1.4 analytical information).
Available logPow data of components
- Lactose:
Read-Across via Trehalose (a,a-D-Trehalose; CAS 99-20-7): -3.77 (Mazzobre et. al., 2005)
Predicted logPow: -5.03 (EPI Suite™ v4.11, KOWWIN v1.68, US EPA, 2018)
(note that Lactose is exempted from REACH registration requirements according to REACH Annex IV (substances included in Annex IV, as sufficient information is known about these substances that they are considered to cause minimum risk because of their intrinsic properties) and can thus be considered to have non-critical properties)
- Lactic acid:
Predicted log Pow -0.7 (XLOGP3-AA method, Kim et. al., 2015)
The main components of the proteins in Bos taurus, milk, fermented, spray-dried (EC 917-734-0) are caseine (80%), serum albumines, beta-lactoglobulines, immunoglobulines and lactalbumines. The following values give an indication that the logPow of these type of proteins should be low:
- Casein:
Predicted logPow -7.1 (XLOGP3-AA method, Kim et. al., 2015)
- Beta-lactoglobulines:
Predicted log Pow -2.4 (XLOGP3-AA method, Kim et. al., 2015)
The logPow does not need to be determined for inorganic constituents. - Conclusions:
- The available log Pow values of the constituents of Bos taurus, milk, fermented, spray-dried (EC 917-734-0) are in the range of -0.7 to -7.1 and thus below 0.
- Executive summary:
The partition coefficient of Bos taurus, milk, fermented, spray-dried (EC 917-734-0) is assessed based on available data on experimental/calculated logPow for its constituents. The available log Pow values of the constituents are in the range of -0.7 to -7.1 and thus below 0.
Reference
Description of key information
The partition coefficient of Bos taurus, milk, fermented, spray-dried (EC 917-734-0) is assessed based on available data on experimental/calculated logPow for its constituents. The available log Pow values of the constituents are in the range of -0.7 to -7.1 and thus below 0.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 0
- at the temperature of:
- 25 °C
Additional information
The partition coefficient of Bos taurus, milk, fermented, spray-dried (EC 917-734-0) is assessed based on available data on experimental/calculated logPow for its constituents. The available log Pow values of the constituents are in the range of -0.7 to -7.1 and thus below 0.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.