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Diss Factsheets
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EC number: 218-320-6 | CAS number: 2116-84-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only a brief report was available for review. The study predates guidelines and GLP.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The study was carried out to see if there was any evidence for repeated administration of the test substance causing reduction in weight of testicles
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 1,1,5,5,5-hexamethyl-3-phenyl-3-[(trimethylsilyl)oxy]trisiloxane
- EC Number:
- 218-320-6
- EC Name:
- 1,1,5,5,5-hexamethyl-3-phenyl-3-[(trimethylsilyl)oxy]trisiloxane
- Cas Number:
- 2116-84-9
- Molecular formula:
- C15H32O3Si4
- IUPAC Name:
- 1,1,5,5,5-hexamethyl-3-phenyl-3-[(trimethylsilyl)oxy]trisiloxane
- Reference substance name:
- Tris(trimethylsiloxy)phenylsilane
- IUPAC Name:
- Tris(trimethylsiloxy)phenylsilane
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No details given in study report
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: oil
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- twenty days
- Frequency of treatment:
- Daily, five days a week, for four weeks
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100, 300, 1000 mg/kg bw
- No. of animals per sex per dose:
- Twenty
- Control animals:
- yes
Examinations
- Observations and examinations performed and frequency:
- Daily observations for condition, weekly bodyweight determination
- Sacrifice and pathology:
- Animals were sacrificed 24 hours after the final dose and the testicles were weighed and examined microscopically.
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Description (incidence and severity):
- on testicle weight
- Histopathological findings: non-neoplastic:
- no effects observed
- Description (incidence and severity):
- on testicle histology
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- > 1 000 mg/kg bw/day (nominal)
- Sex:
- male
- Basis for effect level:
- other: No change in bodyweight or effects on testicle weight or histology was observed.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- In a very limited non-guideline study conducted prior to the introduction of GLP, (trimethylsiloxy)phenylsilane was administered daily by oral gavage, five days a week for four weeks, at doses of 100, 300 and 1000 mg/kg bw/day. No mortalities occurred and no test substance-induced effects on condition or body weight gain were observed in the course of the study. On final sacrifice no effects on weight or histology of testicles were recorded and it is concluded by the reviewer that the NOAEL for effects on body weight and testicle weight and histology is > 1000 mg/kg bw/day.
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