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Diss Factsheets
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EC number: 701-436-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to the O.E.C.D. test guideline 203 with GLP compliance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reaction products of 2-methylimidazole and 2,2'-[(1- methylethylidene)bis(4,1-phenyleneoxymethylene)]bisoxirane
- EC Number:
- 701-436-0
- Molecular formula:
- (C15H16O2.C4H6N2.C3H5ClO)x
- IUPAC Name:
- Reaction products of 2-methylimidazole and 2,2'-[(1- methylethylidene)bis(4,1-phenyleneoxymethylene)]bisoxirane
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- As per IUCLID5 Sections 1.1. 1.2. 1.4. and 4.1.
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
- Details on test solutions:
- For test concentrations prepared in the definitive test, stock solutions were prepared for each concentration individually by adding the required nominal amount of test substance in the diluent (Laboratory grade water), and mixing the solution for approximately 1 hour.
Test organisms
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- The Rainbow Trout, Oncorhynchus mykiss, were acquired from Trout Lodge Trout Farm (Sumner, Washington). The trout had a weight range of 0.441-0.687 gm and a length of 29-3 5 mm when placed on study. The fish were maintained in 2-gallon glass aquaria; filled with 8 L of moderately hard laboratory freshwater. There was a 16-hours light/8-hours dark cycle, a dissolved oxygen concentration of>60% saturation and temperature of 14-15°C. All the fish for the study were held in the laboratory at least 12 days before they were used for testing and The fish placed on study were held in water of the quality used in the test for at least seven days immediately before testing. The fish were fed daily until the test was started. Fish were not fed during the test.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- None
Test conditions
- Hardness:
- Total hardness of 85 mg/L CaCO3
- Test temperature:
- 14-15°C
- pH:
- 7.6
- Dissolved oxygen:
- >60% saturation
- Salinity:
- No data
- Nominal and measured concentrations:
- 10,20,40, 80 and 160 mg/L nominal.
- Details on test conditions:
- Each concentration of test substance consisted of three replicates of ten fish. The fish were randomly placed, individually, into each aquarium containing the appropriate concentration of test substance. The loading rate was up to 1.0 gm fish/L. Three replicates of ten organisms were not exposed to test substance and served as controls to demonstrate the condition of the test population. At 6, 24, 48, 72 and 96 hours following dosing, each aquarium was examined for mortality, and the number of live fish was recorded.
- Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 160 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- Survival of the fish was approximately 100 % at all concentrations.
- Results with reference substance (positive control):
- Not applicable.
- Reported statistics and error estimates:
- The NOEC (No Observed Effect Concentration) and LC50 (median lethal concentration) were determined by a commercially available statistical program (ToxCalc Version 5 .0Th1). Linear Interpolation was selected for the determination in this study..
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test substance had an LC50 for trout of > 160 mgL under the conditions of the study.
- Executive summary:
The test substance, Bisphenol A, epichlorohydrin polymer, 2-methylimidazole condensate, was evaluated for acute toxicity to the Rainbow trout in an O.E.C.D. test guideline 203 study. No mortality was observed in thsi study, Therefore, The test substance had an LC50 for trout of > 160 mgL under the conditions of the study.
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