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EC number: 273-606-8 | CAS number: 68990-52-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 1984-05-17 To 1984-08-08
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: 1a: The study is closely comparable to OECD guideline 401 and is GLP.
- Qualifier:
- according to guideline
- Guideline:
- other: AFNOR NF T 03-021
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- other: Sprague-Dawley/ Crl: CD (SD) BR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River France (76410 Saint Aubin les Elbeuf, France)
- Age at study initiation: no data
- Weight at study initiation: 206 g (males) and 198 g (females)
- Fasting period before study: 17h to 17h20
- Housing: in groups of 5 in polycarbonate cage (42.0 x 27.0 x 15.0 cm)
- Diet (e.g. ad libitum): pelleted standard n° 1 Expanded SQC rat/mouse maintenance diet (Special Diets Services, Witham, Essex, U.K.), ad libitum
- Water (e.g. ad libitum): filtrated water with F.G. millipore membrane (0.2 µm), ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 +/- 3°C
- Humidity (%): 50 % +/- 20 %
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12 hrs dark/ 12 hrs light
IN-LIFE DATES: no data - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE: No vehicle
MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg bw
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 animals per sex per dose
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
mortality and clinical signs: daily after administration
body weight: days 0, 4, 7, 14
- Necropsy of survivors performed: yes
- Other examinations performed: macroscopic examination - Statistics:
- No
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- No mortality at 5000 mg/kg bw.
- Clinical signs:
- other: From 10 minutes to 3 hours after administration, hypokinesia were noticed in all animals. No clinical signs from 3 hours to day 14.
- Gross pathology:
- no macroscopic findings were recorded at necropsy
- Other findings:
- no data
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Metiloil A was not considered to be an acute oral toxic.
- Executive summary:
In an acute oral toxicity study (Kaysen A, 1984), groups of fasted, Sprague-Dawley Crl rats (5 males and 5 females) were given a single oral dose of metiloil A (batch No. 1169) at dose of 5 000 mg/kg bw and observed for 14 days. Oral LD0 (combined sex) is greater than 5000 mg/kg bw (limit test). No mortality was observed. From 10 minutes to 3 hours after administration, hypokinesia was noticed in all animals. Then, no clinical signs were observed. No effect on body weight was observed at the end of the observation period. Metiloil A is not classified based on the LD50 combined sex. This acute oral study is classified as acceptable. It does satisfy the guideline requirement (OECD 401) for an acute oral study in the rats.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
All studies on the substance and on the category members from primary and secondary literature reported no effect at the tested doses of 2000 or 5000 mg/Kg/bw for both oral and dermal routes. Inhalation route is not relevant based on exposure consideration and physical chemical properties of the substance.
Justification for classification or non-classification
Classification is only relevant for LD50 < 2000 mg/kg from any route of exposure and none of the tests have indicated such a result.
No classification for acute toxicity is warranted under 67/548/EEC or Regulation 1272/2008.
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