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Diss Factsheets
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EC number: 215-105-9 | CAS number: 1302-67-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2009-05-05 - 2009-06-22
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: ICCVAm Test Method Evaluation Report: Appendix G, ICCVAM recommended HET-CAM Method protocol (Nov. 2006)
- Deviations:
- yes
- Remarks:
- Eggs were not candled on the eighth day, but on the day of beginning of the study .
- Principles of method if other than guideline:
- ICCVAm test Method Evaluation Report: Appendix G - ICCVAM recommended HET-CAM method Protocol (Nov.2006)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Spinel (Mg(AlO2)2)
- EC Number:
- 215-105-9
- EC Name:
- Spinel (Mg(AlO2)2)
- Cas Number:
- 1302-67-6
- Molecular formula:
- AlO2.1/2Mg
- IUPAC Name:
- magnesium dialuminium oxide
- Details on test material:
- Purity > 99%
Batch no. SP-AR78 -20MY, batch: 082519351
Expiry date: unlimited
Constituent 1
Test animals / tissue source
- Species:
- other: chicken's eggs
- Strain:
- other: Leghorn's chicken's eggs
- Details on test animals or tissues and environmental conditions:
- Species: Lohmann selected Leghorn chicken's eggs
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Negative control: physiol. sodium chloride solution
- Duration of treatment / exposure:
- 300 seconds
- Observation period (in vivo):
- 300 seconds
- Number of animals or in vitro replicates:
- 6 chicken eggs
Results and discussion
In vitro
Results
- Irritation parameter:
- in vitro irritation score
- Value:
- 0
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Any other information on results incl. tables
Test Group |
Irritation Score |
Mean Irritation Score |
Negative Control |
0.00 |
0.00 |
Negative Control |
0.00 |
|
Negative Control |
0.00 |
|
Positive Control 0.1 NaOH |
19.41 |
19.43 |
Positive Control 0.1 NaOH |
19.38 |
|
Positive Control 0.1 NaOH |
19.52 |
|
Positive Control 1% SDS |
10.57 |
10.58 |
Positive Control 1% SDS |
10.63 |
|
Positive Control 1% SDS |
10.53 |
|
Spinel |
0.00 |
0.00 |
Spinel |
0.00 |
|
Spinel |
0.00 |
|
Spinel |
0.00 |
|
Spinel |
0.00 |
|
Spinel |
0.00 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Both positive controls (sodium dodecyl sulfate 1 %) induced severe irritation on the blood vessels. The irritation score for the positive controls lay within the demanded range. The negative control showed no irritation. The test item was tested pure. A mean irritation score of 0.0 was calculated, corresponding to a classification as not irritant.
- Executive summary:
This in vitro study was performed to assess the irritating potential of Spinel by detection of damages in blood vessels under the chorionallantoic membrane of incubated chicken eggs (nine days old). Observation time was 5 minutes at room temperature.
Physiological sodium chloride solution was used as negative control, sodium dodecyl sulfate (1% solution ) and sodium hydroxide (0.1-n solution) were used as positive controls.
Both positive controls induced severe irritation on the blood vessels. The irritation score for the positive controls lay within the demanded range. The negative control showed no irritation.
The test item was tested pure. A mean irritation score of 0.0 was calculated, corresponding to a classification as not irritant.
No observations were made which might cause doubts concerning the validity of the study outcome. The test is considered valid.
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