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Diss Factsheets
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EC number: 200-712-3 | CAS number: 69-72-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented following scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- In vivo percutaneous absorption of chemicals: a multiple dose study in rhesus monkeys
- Author:
- Bucks DAW, Hinz RS, Sarason R et al
- Year:
- 1 990
- Bibliographic source:
- Chem. Toxic. 28(2), 129-132
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The chemical was administered in a small volume to a lightly clipped area of the abdomen on a single- or multiple-dose exposure. Then, percutaneous absorption and urinary elimination were investigated.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Salicylic acid
- EC Number:
- 200-712-3
- EC Name:
- Salicylic acid
- Cas Number:
- 69-72-7
- Molecular formula:
- C7H6O3
- IUPAC Name:
- 2-hydroxybenzoic acid
- Details on test material:
- Name of test material (as cited in study report): salicylic acid
- Radiochemical purity (if radiolabelling): greater than 95 %
- Specific activity (if radiolabelling): 27 mCi/mM
- Locations of the label (if radiolabelling): 14C-carboxyl
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- monkey
- Strain:
- other: macaca mulatta (rhesus)
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: California Primate Research Center (davis, CA)
- Age at study initiation: 7+/-3 yr
- Weight at study initiation: 5 +/- 2 kg
- Fasting period before study: data not available
- Housing: data not available
- Individual metabolism cages: no data
- Diet : ad libitum- Water : ad libitum
- Acclimation period: data not available
ENVIRONMENTAL CONDITIONS
data not available
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- acetone
- Duration of exposure:
- 14 days
- Doses:
- Females: 4 mg/cm²
- No. of animals per group:
- 4
- Details on study design:
- TEST SITE
- Area of exposure: a lightly clipped area of the abdomen
- % coverage: no data
- Type of wrap if used: no data
- Time intervals for shavings or clipplings: no data
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with soap and water (for single-dose experiments only)
- Time after start of exposure: 24hr
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 4 mg/cm2
VEHICLE- Justification for use and choice of vehicle (if other than water): no data
USE OF RESTRAINERS FOR PREVENTING INGESTION:
yes (in the multiple-application experiments)
PHARMACOKINETIC STUDY (absorption, excretion)
- Tissues and body fluids sampled : urine
- Time and frequency of sampling: day 1: 0-4, 4-8, 8-12 and 12-24 hr; day 2-7: urine for each 24-hr period was combined
Results and discussion
- Signs and symptoms of toxicity:
- not specified
- Dermal irritation:
- not specified
Any other information on results incl. tables
Penetration rate:
• Single application: 59 ± 32 %
• 14-day application (cumulative absorption):
1st day: 67 ± 17 %
8th day: 78 ± 18 %
Salicylic acid was absorbed across the skin. The amount penetrating from a single application could not be distinguished from that absorbed following a 14-day multiple application protocol.
Applicant's summary and conclusion
- Conclusions:
- No significant change in percutaneous absorption from that following the initial dose was observed following the eighth daily dose of a 14-day multidose regimen for each of the three penetrants considered. Cumulative percentage of 14C dose absorbed through the skin for SA: single dose: 59 ± 32 %; multiple dose: 1st one = 67 ± 17 %, 8th dose = 78 ± 18 %.
- Executive summary:
In a percutaneous absorption (Bucks et al., 1990), salicylic acid was administered at a surface dose of 4 mg/cm² to a lightly clipped area of the abdomen either in a single-dose exposure or in a multiple-dose exposure. To quantify absorption, urine was collected for 7 days after dosing. Percutaneous absorption was observed. The amount penetrating from a single application (59 ± 32 %) could not be distinguished from that absorbed following either the first (67 ± 17 %) or the eighth (78 ± 18 %) daily dose of a 14-day multiple application protocol. Thus, under the conditions used, measurement of percutaneous absorption after a single application can be predictive of permeation when multiple skin contacts occur.
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