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Diss Factsheets
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EC number: 203-765-0 | CAS number: 110-41-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards with acceptable restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 4 rabbits were dermally exposed to the test material for 24 hr and then observed for a further 24 hours for mortality. The first attempt at this experiment was ended early; the study was repeated with 3 new rabbits.
- GLP compliance:
- no
- Remarks:
- Study predates GLP
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- 2-methylundecanal
- EC Number:
- 203-765-0
- EC Name:
- 2-methylundecanal
- Cas Number:
- 110-41-8
- Molecular formula:
- C12H24O
- IUPAC Name:
- 2-methylundecanal
Constituent 1
- Specific details on test material used for the study:
- - Names of test material: RIFM 71-16, aldehyde C-12 MNA
- Substance type: Clear liquid
- Physical state: Liquid
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: 2.6 to 3.0 kg
- Fasting period before study: No data
- Housing: No data
- Diet: No data
- Water: No data
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod: No data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: No data
- % coverage: No data
- Type of wrap: wrap described as "damming" - no further information.
REMOVAL OF TEST SUBSTANCE
- Washing: Water
- Time after start of exposure: 24 hr
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): No data
- Constant volume or concentration used: No - Duration of exposure:
- 24 hr
- Doses:
- 10 mL/kg
- No. of animals per sex per dose:
- 2 male, 2 female (test group 1)
2 male, 1 female (test group 2) - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 10 days (test group 1); 14 days (test group 2)
- Frequency of observations and weighing:
-- Test group 1: Observations every day from days 1-10; weighing on days 0, 3, 7, 10.
-- Test group 2: Observations every day from days 1-14; weighing on days 0, 3, 7, 10, 14.
- Necropsy of survivors performed: Yes
- Other examinations performed: Body weight, skin irritation (erythema, oedema). - Statistics:
- No data
Results and discussion
- Preliminary study:
- No preliminary study
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Equivalent to 8280 mg/kg bw when multiplied by density of 828 mg/mL.
- Mortality:
- No animals died during the study.
- Clinical signs:
- other: See attached results. Oedema was replaced by a shell of hard peeling skin in rabbits 1A♂ and 1U♂ by day 7 (test group 1) and 8A♂ by day 6 (test group 2).
- Gross pathology:
- Autopsy revealed no unusual findings.
- Other findings:
- No data
Any other information on results incl. tables
Please refer to the attached background material.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test material was assessed for acute dermal toxicity using rabbits. The test material was not acutely toxic to rabbits via the dermal route at a concentration of 10 mL/kg bw.
Multiplying this value by the density value of 828 mg/mL gives a value of 8280 mg/kg bw.
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