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Diss Factsheets
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EC number: 203-807-8 | CAS number: 110-83-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- screening for reproductive / developmental toxicity
- Remarks:
- based on test type (migrated information)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 422 (Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Cyclohexene
- EC Number:
- 203-807-8
- EC Name:
- Cyclohexene
- Cas Number:
- 110-83-8
- Molecular formula:
- C6H10
- IUPAC Name:
- cyclohexene
- Details on test material:
- - Analytical purity:98.6wt%
- Impurities (identity and concentrations):0.01wt% BHT(2,6-Di-tert-butyl-4-methylphenol) is included as antioxidant
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
Results and discussion
Results: P0 (first parental generation)
Effect levels (P0)
- Dose descriptor:
- NOAEL
- Effect level:
- 500 mg/kg bw/day
- Sex:
- male/female
Results: F1 generation
Effect levels (F1)
- Dose descriptor:
- NOAEL
- Generation:
- F1
- Effect level:
- 500 mg/kg bw/day
- Sex:
- male/female
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
- Mortality: There was no mortality related to the test substance treatment. Clinical signs: Salivation was apparent in three animals of 150 mg/kg b.w. group and in twelve animals of 500 mg/kg b.w. group for males and in two animals of 150 mg/kg b.w. group and twelve animals of 500 mg/kg b.w. group for females. Although the grades of salivation were not reported, the sign was observed for about 5 minutes after dosing at 150 mg/kg b.w. , and for 30 minutes to 5 hours after dosing at 500 mg/kg b.w. during treatment period. In addition, lacrimation was observed in two animals of 500 mg/kg b.w. group for males and in one animal each of 150 and 500 mg/kg b.w. groups for females. The onsets and grades of lacrimation were not reported.
- Body weight: No statistically significant changes for males and females. Food consumption: No effects for males and females.
- Urinalysis: No statistically significant changes.
- Hematology: No effects for males and females
- Blood biochemistry:
Males: Decreases in triglyceride in 150 and 500 mg/kg b.w. groups, increases in total bilirubin in 500 mg/kg b.w. group, and total bile acid in 150 and 500 mg/kg b.w..
Females: Increase in total bile acid in 50, 150, and 500mg/kg b.w..
- Necropsy and histopathology: No adverse effects for males and females.
- Organ weights:
Males: Increase in a relative kidney weight in 500 mg/kg b.w. group.
Females: No statistically changes. Histopathology: No changes related to test substance.
- Reproductive and developmental parameters: No effects observed on reproductive performance in males and females given each dose, and developmental performance of the newborns.
Applicant's summary and conclusion
- Conclusions:
- In an OECD combined study, there are no effects of cyclohexene on reproduction/developmental parameters. The NOAEL for reproduction/developmental toxcity is considered to be 500mg/kg b.w./day.
- Executive summary:
In an OECD combined study, there are no effects of cyclohexene on reproduction/developmental parameters. The NOAEL for reproduction/developmental toxcity is considered to be 500mg/kg b.w./day.
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