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EC number: 233-302-8 | CAS number: 10109-95-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well performed GLP and OECD guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2,5-dianilinoterephthalic acid
- EC Number:
- 233-302-8
- EC Name:
- 2,5-dianilinoterephthalic acid
- Cas Number:
- 10109-95-2
- Molecular formula:
- C20H16N2O4
- IUPAC Name:
- 2,5-bis(phenylamino)benzene-1,4-dicarboxylic acid
- Details on test material:
- - Name of test material (as cited in study report): Anilosäure (Dianiloterephthalsäure, 2,5-Dianiloterephthalsäure)
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- - Source: Hoechst AG breed colony
- Age at study initiation: 3 to 5 months
- Weight at study initiation: 2.7 kg to 3.3 kg
- Housing: Individually in stainless steel cages
- Diet (e.g. ad libitum): standard laboratory diet (Altromin 2123) ad libitum, appr. 15 g hay daily
- Water (e.g. ad libitum): deionized chlorinated water, ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20° ± 3°C (air-condition)
- Humidity (%): 50 ± 20%
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the untreated eye of each rabbit served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 100 mg of the undiluted (unchanged) test substance - Duration of treatment / exposure:
- Treatment: Single application
Exposure: 24 h, at the end of the exposure period eyes were rinsed with physiol. saline - Observation period (in vivo):
- 3 days
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- Application of the substance to the conjunctival sac of the left eye of each animal, the right eyes served as control respectively
REMOVAL OF TEST SUBSTANCE
- Washing: Washing with physiological saline at approx. 37 °C 24 h after administration and at all other designated examination times at which the treated eyes still showed discharge or at which a corneal examination with fluorescein sodium solution (24, 48 and 72 h after administration) took place
TOOL USED TO ASSESS SCORE: 0.01 % solution of fluorescein sodium, under UV light
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: # 59, 60, 100 each
- Time point:
- other: mean of 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no signs of irritation (cornea) at any time
- Irritation parameter:
- iris score
- Basis:
- animal: # 59, 60, 100 each
- Time point:
- other: mean of 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- other: no signs of irritation (iris) at any time
- Irritation parameter:
- chemosis score
- Basis:
- animal: # 59, 60, 100 each
- Time point:
- other: mean of 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no signs of irritation (chemosis) at any time
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: # 59, 60, 100 each
- Time point:
- other: mean of 24, 48 and 72 h
- Score:
- 0
- Max. score:
- 3
- Reversibility:
- other: initial slight effects were fully reversible within 24 h
- Other effects:
- Violet discharge was observed at 1 hour after application
Any other information on results incl. tables
Animal no |
Sex |
Evaluation Interval |
Cornea |
Conjunctiva |
Iris |
||
|
|
|
Opacity |
Redness |
Chemosis |
Discharge |
|
59 |
F |
1 h |
0 |
1 |
0 |
1 |
0 |
60 |
0 |
1 |
0 |
1 |
0 |
||
100 |
0 |
1 |
0 |
1 |
0 |
||
59 |
F |
24 h |
0 |
0 |
0 |
0 |
0 |
60 |
0 |
0 |
0 |
0 |
0 |
||
100 |
0 |
0 |
0 |
0 |
0 |
||
59 |
F |
48 h |
0 |
0 |
0 |
0 |
0 |
60 |
0 |
0 |
0 |
0 |
0 |
||
100 |
0 |
0 |
0 |
0 |
0 |
||
59 |
F |
72 h |
0 |
0 |
0 |
0 |
0 |
60 |
0 |
0 |
0 |
0 |
0 |
||
100 |
0 |
0 |
0 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- not irritating to the eye
- Executive summary:
A study with the test item according to OECD Guideline 405 was performed to investigate the irritation potential to the rabbit eye.
One hour after treatment the conjunctivae of the animals showed definitely injected blood vessels. Additionally substance coloured eye discharge was observed in the animals one hour after treatment. 24 hours after treatment all signs of irritation were reversible.
Testing of Anilosäure for primary eye irritation in the rabbit showed that the substance is not irritating to the eye.
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