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EC number: 225-969-9 | CAS number: 5188-07-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Sodium methanethiolate
- EC Number:
- 225-969-9
- EC Name:
- Sodium methanethiolate
- Cas Number:
- 5188-07-8
- Molecular formula:
- CH4S.Na
- IUPAC Name:
- sodium methylsulfanide
- Details on test material:
- Test article name : Sodium methylmercaptide
CAS RN°: 5188-07-8
Origin: Elf Aquitaine, Lacq
Batch: 93-7074
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Iffa Crédo, 69210 L'Arbresle, France
- Age at study initiation: ca. 8 weeks
- Weight at study initiation: 271 +/- 14 g for males and 230 +/- 8 g for females
- Fasting period before study:
- Housing: 4 to 7 in polycarbonate cages
- Diet (ad libitum): UAR A04 C
- Water (e.g. ad libitum): filtered tap water
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3
- Humidity (%): 50 +/-20
- Air changes (per hr): 13 cycles/hr of filtered, non-recycled air
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- water
- Details on dermal exposure:
- Sodium methylmercaptide (21.2% solution in water) was administered by dermal route to a group of 10 Sprague-Dawley rats (5 males and 5 females). As the test substance was anticipated to be corrosive, 2 animals were used in a first assay. The test substance in its original form was applied directly to the skin at a dose of 2000 mg/kg (i.e. 424 mg/kg in raw material), taking into consideration that the specific gravity (SG) of the test substance was 1.12. In a second assay, on 8 animals (4 males and 4 females), the test substance at a dose of 400 mg/kg (i.e. 84.8 mg/kg in raw material) was dissolved in water and applied directly to the skin in a volume of 5 ml/kg.
After 24 hours under a semi-occlusive dressing, no residual test substance was observed on removal of the dressing. - Doses:
- 2000 and 400 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Details on study design:
- The animals given 400 mg/kg were checked for clinical signs, mortality and body weight gain for a period of 14 days following the single application of the test substance.
A necropsy was performed on each animal sacrificed during the study or sacrificed at the end of the study.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 84.8 mg/kg bw
- Based on:
- act. ingr.
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 400 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 21.2% solution in water
- Mortality:
- At 2000 mg/kg, the 2 treated animals were sacrificed on day 2 for humane reasons.
At 400 mg/kg no deaths were noted. - Clinical signs:
- other: At 2000 mg/kg, tissue lesions on the whole depth of the skin (necrosis) were noted after removal of the dressing on day 2. At 400 mg/kg, no cutaneous reactions was noted. Hypoactivity, tremors were noted on day 2 in one female. No clinical signs and no
- Gross pathology:
- No macroscopic lesions were observed at necropsy.
Applicant's summary and conclusion
- Conclusions:
- The LD0 of SODIUM METHYLMER-CAPTIDE when administered by dermal route in rats was > 400 mg/kg using the formulated test substance (21.2% in water) or > 84.8 mg/kg using the pure test substance.
- Executive summary:
Sodium methanethiolate (21.2% solution in water) was applied directly to the skin of one male and one female rat at 2000 mg/kg body weight (424 mg active ingredient (a.i.) /kg bw) in an OECD TG 402 study. After occlusion for 24 hours, tissue lesions on the whole depth of the skin were noted and these animals were euthanized for humane reasons. Eight additional rats (4/sex) were dosed with 400 mg/kg bw test solution in water (84.8 mg a.i. /kg bw). The dose site was wrapped with a semi-occlusive dressing for 24 hours. Two females exhibited reversible body weight loss and clinical signs that included hypoactivity and tremors between days 1 and 5. No cutaneous reactions or deaths were observed for any of the animals over the 14-day observation period, resulting in LD50of >400 mg/kg bw for the 21.2% water solution and > 84.8 mg/kg bw for the active ingredient.
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