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Diss Factsheets
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EC number: 200-935-6 | CAS number: 76-12-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vivo
Description of key information
Link to relevant study records
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- other: discussion based on literature data
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The source is considered reliable since the reported information is based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.
- Principles of method if other than guideline:
- not documented
- GLP compliance:
- not specified
- Type of assay:
- rodent dominant lethal assay
- Species:
- rat
- Sex:
- female
- Route of administration:
- intraperitoneal
- Duration of treatment / exposure:
- 8 weeks, prior to mating
- Remarks:
- Doses / Concentrations:
200 mg/kg bw
Basis: - Remarks:
- Doses / Concentrations:
1000 mg/kg bw
Basis: - Conclusions:
- Interpretation of results (migrated information): negative
No increase in dominant lethal was seen in female rats. - Executive summary:
The American Conference of Governmental Industrial Hygienists(ACGIH) is a professional association of industrial hygienists and practitioners of related professions. One of the goals of the association is to provide information and guideline on exposure limits of substances in order to advance worker protection and to this purpose data deriving from scientific literature were rewieved.
The result of a dominant lethal assay is reported. Under the study, females rats were treated with intraperitoneal injections of either 200 or 1000 mg/kg for eight weeks before mating with untreated male rats.
No increase in dominant lethal was seen.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
The American Conference of Governmental Industrial Hygienists(ACGIH) is a professional association of industrial hygienists and practitioners of related professions. One of the goals of the association is to provide information and guideline on exposure limits of substances in order to advance worker protection, and to this purpose the available scientific data on target substances are revised.
ACGIH summaries are based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences, therefore ACGIH is considered a reliable secondary source of information.
For genetic toxicity the results deriving from two studies are reported: an Ames test in Salmonella Typhimurium and a Dominant lethal assay in rats.
According to the results, 1,1,2,2 -tetrachloro-1,2-difluoroethane appeared to be weakly positive when tested in the Ames test and complete negative when tested under the dominant lethal assay in rats.
Basing on the results, and considering that the in vivo study better estimates the real potential for genetic toxicity on humans, 1,1,2,2-tetrachloro-1,2-difluoroethane cannot be considered as genotoxic.
However, it has to be noted that a complete assessment of the potential for genetic toxicity of 1,1,2,2-tetrachloro-1,2-difluoroethan was not performed.
Justification for selection of genetic toxicity endpoint
The reported reference is a secondary source which discusses the available literature data.
For genetic toxicity two results are reported, an in vitro and an in vivo study.
Since the in vivo study is considered to better estimate the real potential for genetic toxicity on humans, the reference was selected as key result.
Justification for classification or non-classification
The reported information is not sufficient to support a classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.