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EC number: 200-935-6 | CAS number: 76-12-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
A reliable secondary source is reported as reference, which discusses the available literature data.
The results of several repeted dose toxicity studies are reported.
Basing on the exisiting data, 1,1,2,2-tetrachloro-1,2-difluoroethane does not meet the classification criteria for hazard classes related to repeated dose exposure according to Regulation (EC) No. 1272/2008.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Link to relevant study records
- Endpoint:
- repeated dose toxicity: oral
- Remarks:
- other: not specified
- Type of information:
- other: discussion based on literature data
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The source is considered reliable since reported information is based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.
- Reason / purpose for cross-reference:
- reference to same study
- Principles of method if other than guideline:
- Discussion on literature data of subacute toxicty by oral route.
- GLP compliance:
- not specified
- Species:
- other: Rat, Mouse, Guinea pig, Rabbit
- Dose descriptor:
- NOEL
- Effect level:
- 125 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- not specified
- Critical effects observed:
- not specified
- Executive summary:
The American Conference of Governmental Industrial Hygienists(ACGIH) is a professional association of industrial hygienists and practitioners of related professions. One of the goals of the association is to provide information and guideline on exposure limits of substances in order to advance worker protection. ACGIH sheets are based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences and therefore ACGIH is considered a reliable secondary source of information.
The results of several repeted dose toxicity studies are reported.
According to the reference, the NOEL of 125 mg/kg bw is derived from the 21 -day repeated dose toxicity study on rats.
1,1,2,2-tetrachloro-1,2-difluoroethane does not meet the classification criteria for hazard classes related to repeated dose exposure by oral route according to Regulation (EC) No. 1272/2008.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- 125 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- The reference reports a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.
Repeated dose toxicity: inhalation - systemic effects
Link to relevant study records
- Endpoint:
- repeated dose toxicity: inhalation
- Remarks:
- other: not specified
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The source is considered reliable since reported information is based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.
- Principles of method if other than guideline:
- discussion on literature data of subchronic and subacute toxicty by inhalation.
- GLP compliance:
- not specified
- Species:
- other: Rat, Mouse, Guinea pig, Rabbit
- Dose descriptor:
- LOEC
- Effect level:
- 500 ppm
- Based on:
- test mat.
- Sex:
- not specified
- Critical effects observed:
- not specified
- Executive summary:
The American Conference of Governmental Industrial Hygienists(ACGIH) is a professional association of industrial hygienists and practitioners of related professions. One of the goals of the association is to provide information and guideline on exposure limits of substances in order to advance worker protection. ACGIHsheets are based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences and therefore ACGIH is considered a reliable secondary source of information.
The results of several repeted dose toxicity studies are reported.
1,1,2,2-tetrachloro-1,2-difluoroethanedoes not meet the classification criteria for hazard classes related to repeated dose exposure by inhalation according to Regulation (EC) No. 1272/2008.
Reference
The following studies and results are reported under ACGIH sheet:
Tested animals |
Concentration |
Exposure |
Significant results and main clinical signs |
Reference |
10 rats |
500 ppm |
7 hours/day |
Irritation of the bronchiolar passages at 1000 ppm. |
Sax, 1975 |
16 guinea pigs |
500 ppm |
7 hours/day |
Fatty degeneration, necrosis and regenerative changes of the liver. |
Sax, 1975 |
4 rabbits |
500 ppm |
7 hours/day |
No information on results reported. |
Sax, 1975 |
10 rats |
|
6 hours/day |
The only significan sign of toxicity was a reduction in weight gain. |
DuPont Company, 1947, 1963 |
16 rats |
1000 ppm |
6 hours/day |
No clinical signs of systemic toxicity.Body weights of animals were within normal limits.Gross pathology and histopathology relealed very minor changes in the liver and slight aggravation of the usual type of pneumonitis seen in the rat strain employed |
Clayton et al, 1967 |
10 mice |
1000 ppm |
6 hours/day |
No clinical signs of systemic toxicity.Body weights of animals were within normal limits. |
Clayton et al, 1967 |
2 guinea pigs |
1000 ppm |
6 hours/day |
No clinical signs of systemic toxicity.Body weights of animals were within normal limits. |
Clayton et al, 1967 |
1 rabbit |
1000 ppm |
6 hours/day |
No clinical signs of systemic toxicity.Body weights of animals were within normal limits. |
Clayton et al, 1967 |
5 rats |
1000 ppm |
18 hours/day |
No effect. |
Gage, 1970 |
rats |
3000 ppm |
4 hours/day |
CNS and respiratory signs. No deaths. |
Gage, 1970 |
4 rats |
5000 ppm |
4 hours/day |
Signs of discomfort, muscular incoordination, slight narcosis during exposure with rapid recovery. |
Gage, 1970 |
4 rats |
2500 ppm |
4 hours/day |
Same signs of discomfort, muscular incoordination, and slight narcosis during exposure. Milder than the observed ones at exposure of 5000 ppm. Rapid recovery. |
Gage, 1970 |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LOAEC
- 4 167.69 mg/m³
- Study duration:
- subchronic
- Species:
- guinea pig
- Quality of whole database:
- The reference reports a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.
Repeated dose toxicity: inhalation - local effects
Link to relevant study records
- Endpoint:
- repeated dose toxicity: inhalation
- Remarks:
- other: not specified
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The source is considered reliable since reported information is based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.
- Principles of method if other than guideline:
- discussion on literature data of subchronic and subacute toxicty by inhalation.
- GLP compliance:
- not specified
- Species:
- other: Rat, Mouse, Guinea pig, Rabbit
- Dose descriptor:
- LOEC
- Effect level:
- 500 ppm
- Based on:
- test mat.
- Sex:
- not specified
- Critical effects observed:
- not specified
- Executive summary:
The American Conference of Governmental Industrial Hygienists(ACGIH) is a professional association of industrial hygienists and practitioners of related professions. One of the goals of the association is to provide information and guideline on exposure limits of substances in order to advance worker protection. ACGIHsheets are based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences and therefore ACGIH is considered a reliable secondary source of information.
The results of several repeted dose toxicity studies are reported.
1,1,2,2-tetrachloro-1,2-difluoroethanedoes not meet the classification criteria for hazard classes related to repeated dose exposure by inhalation according to Regulation (EC) No. 1272/2008.
Reference
The following studies and results are reported under ACGIH sheet:
Tested animals |
Concentration |
Exposure |
Significant results and main clinical signs |
Reference |
10 rats |
500 ppm |
7 hours/day |
Irritation of the bronchiolar passages at 1000 ppm. |
Sax, 1975 |
16 guinea pigs |
500 ppm |
7 hours/day |
Fatty degeneration, necrosis and regenerative changes of the liver. |
Sax, 1975 |
4 rabbits |
500 ppm |
7 hours/day |
No information on results reported. |
Sax, 1975 |
10 rats |
|
6 hours/day |
The only significan sign of toxicity was a reduction in weight gain. |
DuPont Company, 1947, 1963 |
16 rats |
1000 ppm |
6 hours/day |
No clinical signs of systemic toxicity.Body weights of animals were within normal limits.Gross pathology and histopathology relealed very minor changes in the liver and slight aggravation of the usual type of pneumonitis seen in the rat strain employed |
Clayton et al, 1967 |
10 mice |
1000 ppm |
6 hours/day |
No clinical signs of systemic toxicity.Body weights of animals were within normal limits. |
Clayton et al, 1967 |
2 guinea pigs |
1000 ppm |
6 hours/day |
No clinical signs of systemic toxicity.Body weights of animals were within normal limits. |
Clayton et al, 1967 |
1 rabbit |
1000 ppm |
6 hours/day |
No clinical signs of systemic toxicity.Body weights of animals were within normal limits. |
Clayton et al, 1967 |
5 rats |
1000 ppm |
18 hours/day |
No effect. |
Gage, 1970 |
rats |
3000 ppm |
4 hours/day |
CNS and respiratory signs. No deaths. |
Gage, 1970 |
4 rats |
5000 ppm |
4 hours/day |
Signs of discomfort, muscular incoordination, slight narcosis during exposure with rapid recovery. |
Gage, 1970 |
4 rats |
2500 ppm |
4 hours/day |
Same signs of discomfort, muscular incoordination, and slight narcosis during exposure. Milder than the observed ones at exposure of 5000 ppm. Rapid recovery. |
Gage, 1970 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The reference reports a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences.
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Reported data derive from the ACGIH sheet for the substance 1,1,2,2 -tetrachloro-1,2 -difluoroethane.
The American Conference of Governmental Industrial Hygienists(ACGIH) is a professional association of industrial hygienists and practitioners of related professions. One of the goals of the association is to provide information and guideline on exposure limits of substances in order to advance worker protection, and to this purpose the available scientific data on target substances are revised.
ACGIH sheets are based on a review of existing peer-reviewed scientific literature by committees of experts in public health and related sciences, therefore ACGIH is considered a reliable secondary source of information.
The results of several repeted dose toxicity studies are reported.
Justification for selection of repeated dose toxicity via oral route - systemic effects endpoint:
The reported reference is a secondary source which discusses the available literature data. For repeated dose toxicity by oral route several studies are reported.
The reported value is the NOEL derived from a 21-day repeated dose toxicity study on male rats.
Justification for selection of repeated dose toxicity inhalation - systemic effects endpoint:
The reported reference is a secondary source which discusses the available literature data. For repeated dose toxicity by inhalation several studies are reported.
The reported value is the LOAEC derived from a 6-month repeated dose toxicity study on guinea pigs. The study was selected for its length.
Justification for selection of repeated dose toxicity inhalation - local effects endpoint:
The reported reference is a secondary source which discusses the available literature data. For repeated dose toxicity by inhalation several studies are reported.
Justification for classification or non-classification
Basing on the exisiting data, 1,1,2,2-tetrachloro-1,2-difluoroethane does not meet the classification criteria for hazard classes related to repeated dose exposure according to Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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