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Description of key information

Dioctadecyl disulphide applied by gavage to rats was mainly excreted via feces (range: 87.7 - 93 %) indicating a very limited bioaccessibility.Half-life in blood was from 9.6 to 14 hours. Low concentrations of the test substance were found in mesentheric lymph nodes, kidneys and liver.

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential

Additional information

The dispositon of Hostanox SE 10 was investigated in male Wistar rats after single oral doses of 100 and 1000 mg/kg bw. A dose-dependent increase in blood concentration of Hostanox SE 10 was observed and Hostanox SE 10 was cleared from blood within a parent half-life of 14 hours. Maximum blood concentrations of Hostanox SE 10 were reached within 6 hours and were 250 pmol/mL blood. Low concentrations of the test item were also observed in liver, kidney and mesentheric lymphnodes. The data indicate that Hostanox SE 10 absorption from the gastro-intestinal tract is very limited after oral administration and that the absorbed amount of the substance is rapidly cleared from blood. Most of the administered dose (93 +/- 14 %) was recovered in feces within 72 h supporting the observed low bioaccessibility.

The dispositon of Hostanox SE 10 was investigated in male Wistar rats after a single oral dose of 49.5 mg/kg bw. Hostanox SE 10 was cleared from blood within a parent half-life of 9.6 hours. Maximum blood concentration of Hostanox SE 10 was reached 3 hours after application in one of three rats and was 0.18 µg/mL blood. Low concentrations of the test item (< 0.7 or < 0.1 µg/g) were also observed in fat tissue, spleen, heart, pancreas, liver, kidney and mesentheric lymphnodes. The highest concentration was found in adrenals (1.5 µg/g). The data indicate that Hostanox SE 10 absorption from the gastro-intestinal tract is very limited after oral administration and that the absorbed amount of the substance is rapidly cleared from blood. Most of the administered dose (87.7 +/- 10.5 %) was recovered in feces supporting the observed low bioaccessibility.