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EC number: 805-675-2
CAS number: 102340-61-4
An inversely proportional minimal trend to the concentrations was
recorded. This may be explained by the test item being applied diluted
in the vehicule. Therefore, the availability of the test item over the
ear skin and its skin penetration is different.
The objective of the study was to evaluate the potential acute toxicity
of the test item, Tocopheryl Glucoside, to induce contact
hypersensitivity using the murine Local Lymph Node Assay (LLNA). The
study was conducted according the OECD guideline n°429.
The test item was administred by topical application to the dorsal
surface of ears at concentrations of 10%, 25% and 50% (w/v). The test
item was prepared in a acetone/olive oil (4/1, v/V) preparation.
The resultas were expressed as desintegrations per minute (dpm) per
group and as dpm/node. The obtained values were used to calculate de
Stimulation Indice (SI).
Under the experimental conditions of the study, no local reactions were
observed in nay animals, no notable increase in ear thickness was
observed in any tested concentrations. The SI of the positive control
was considered valid. The oberved SI walues were 2.04, 1.87 and 1.58 at
concentrations 10%, 25% &nd 50% respectively. No notable
lymphoproliferation was noted with the test item in any tested
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